Diabetic kidney disease (DKD) is the leading cause of morbidity and mortality in diabetic
patients. Defining risk factors for DKD using a reductionist approach has proven challenging …

Although diabetic kidney disease (DKD) remains the leading cause of end-stage kidney
disease eventually requiring chronic kidney replacement therapy, the prevalence of DKD …

The role of mitochondria in diabetic complications has been viewed as a source of excess
superoxide production leading to cell dysfunction. However, with the lack of benefit of non …

Mitochondrial dysfunction plays an important role in the pathogenesis and progression of
diabetic kidney disease (DKD). In this review, we will discuss mitochondrial dysfunction …

Background Globally, diabetic kidney disease (DKD) is the leading cause of end-stage renal
disease. As the most common microvascular complication of diabetes, DKD is a thorny …

To derive new insights in diabetic complications, we integrated publicly available human
protein-protein interaction (PPI) networks with global metabolic networks using metabolomic …

Focus on the Warburg effect, initially descriptive of increased glycolysis in cancer cells, has
served to illuminate mitochondrial function in many other pathologies. This review explores …

The role and nature of mitochondrial dysfunction in diabetic kidney disease (DKD) has been
extensively studied. Yet, the molecular drivers of mitochondrial remodeling in DKD are …

Diabetes is the leading cause of chronic kidney disease worldwide. Despite the burden, the
factors contributing to the development and progression of diabetic kidney disease (DKD) …

Several lines of evidence suggest that mitochondrial dysfunction plays a critical role in the
pathogenesis of microvascular complications of diabetes, including diabetic nephropathy …