Background Intracellular heme plays versatile roles in a variety of physiological processes
including mitochondrial respiration. Heme also induces the expression of genes such as …

Hemopexin (HPX) transports heme to liver parenchymal cells, undergoes receptor-mediated
endocytosis, and recycles intact. Incubation of mouse hepatoma (Hepa) cells with heme …

Hemopexin (Hx) binds heme with a very high affinity (K d< 0.1 pmol/L). It has been
implicated as a major vehicle for the transport of heme into liver cells, involving a receptor …

Hemopexin (HPX) is the plasma protein with the highest binding affinity to heme among
known proteins. It is mainly expressed in liver, and belongs to acute phase reactants, the …

Background: Hemolytic anemia is associated with intravascular heme release and oxidative
stresses that lead to endothelial dysfunctions. Hemopexin (HPX) is a plasma heme-binding …

Hemopexin (Hx) is a plasma glycoprotein mainly expressed in liver and, less abundantly, in
the central and peripheral nervous systems. Hx has a high binding affinity with heme and is …

Intravascular hemolysis results in the release of massive amounts of hemoglobin and heme
into plasma, where they are rapidly bound by haptoglobin and hemopexin, respectively …

In hemolytic disorders, erythrocyte lysis results in massive release of hemoglobin and,
subsequently, toxic heme. Hemopexin is the major protective factor against heme toxicity in …

Studies with patients, animal models of human disease and hemopexin null mice have
shown that the heme-binding protein hemopexin is vital for the protection of a variety of cell …

Heme is a fundamental molecule for several biological processes, but when released in the
extracellular space such as in hemolytic diseases, it can be toxic to cells and tissues …