Minireview: the circadian clockwork of the suprachiasmatic nuclei—analysis of a cellular oscillator that drives endocrine rhythms

ES Maywood, JS O'Neill, JE Chesham… - …, 2007 - academic.oup.com
The secretion of hormones is temporally precise and periodic, oscillating over hours, days,
and months. The circadian timekeeper within the suprachiasmatic nuclei (SCN) is central to …

Electrophysiology of the suprachiasmatic circadian clock

TM Brown, HD Piggins - Progress in neurobiology, 2007 - Elsevier
In mammals, an internal timekeeping mechanism located in the suprachiasmatic nuclei
(SCN) orchestrates a diverse array of neuroendocrine and physiological parameters to …

Circadian synchrony: sleep, nutrition, and physical activity

KL Healy, AR Morris, AC Liu - Frontiers in network physiology, 2021 - frontiersin.org
The circadian clock in mammals regulates the sleep/wake cycle and many associated
behavioral and physiological processes. The cellular clock mechanism involves a …

Circadian rhythms and hormonal homeostasis: pathophysiological implications

D Gnocchi, G Bruscalupi - Biology, 2017 - mdpi.com
Over recent years, a deeper comprehension of the molecular mechanisms that control
biological clocks and circadian rhythms has been achieved. In fact, many studies have …

The regulation of neuroendocrine function: timing is everything

LJ Kriegsfeld, R Silver - Hormones and behavior, 2006 - Elsevier
Hormone secretion is highly organized temporally, achieving optimal biological functioning
and health. The master clock located in the suprachiasmatic nucleus (SCN) of the …

Circadian rhythms of the hypothalamus: from function to physiology

R Van Drunen, K Eckel-Mahan - Clocks & sleep, 2021 - mdpi.com
The nearly ubiquitous expression of endogenous 24 h oscillations known as circadian
rhythms regulate the timing of physiological functions in the body. These intrinsic rhythms …

Signaling to the circadian clock: plasticity by chromatin remodeling

Y Nakahata, B Grimaldi, S Sahar, J Hirayama… - Current opinion in cell …, 2007 - Elsevier
Circadian rhythms govern several fundamental physiological functions in almost all
organisms, from prokaryotes to humans. The circadian clocks are intrinsic time-tracking …

Coupling the circadian clock to homeostasis: the role of period in timing physiology

P Kim, H Oster, H Lehnert, SM Schmid… - Endocrine …, 2019 - academic.oup.com
A plethora of physiological processes show stable and synchronized daily oscillations that
are either driven or modulated by biological clocks. A circadian pacemaker located in the …

Circadian blueprint of metabolic pathways in the brain

CM Greco, P Sassone–Corsi - Nature Reviews Neuroscience, 2019 - nature.com
The circadian clock is an endogenous, time-tracking system that directs multiple metabolic
and physiological functions required for homeostasis. The master or central clock located …

Ontogeny of circadian rhythms and synchrony in the suprachiasmatic nucleus

V Carmona-Alcocer, JH Abel, TC Sun… - Journal of …, 2018 - Soc Neuroscience
In mammals, the suprachiasmatic nucleus (SCN) of the hypothalamus coordinates daily
rhythms including sleep–wake, hormone release, and gene expression. The cells of the …