Chronopharmacological strategies focused on chrono-drug discovery

S Ohdo, S Koyanagi, N Matsunaga - Pharmacology & therapeutics, 2019 - Elsevier
In mammals, the circadian pacemaker resides in the paired suprachiasmatic nuclei (SCN)
and influences a multitude of biological processes, including the sleep–wake rhythm …

The circadian rhythm of glucocorticoids is regulated by a gating mechanism residing in the adrenal cortical clock

H Oster, S Damerow, S Kiessling, V Jakubcakova… - Cell metabolism, 2006 - cell.com
In mammals, the master clock of the suprachiasmatic nuclei (SCN) and subordinate clocks
found throughout the body coordinate circadian rhythms of behavior and physiology. We …

Challenging the omnipotence of the suprachiasmatic timekeeper: are circadian oscillators present throughout the mammalian brain?

C Guilding, HD Piggins - European Journal of Neuroscience, 2007 - Wiley Online Library
The suprachiasmatic nucleus of the hypothalamus (SCN) is the master circadian pacemaker
or clock in the mammalian brain. Canonical theory holds that the output from this single …

Circadian clock control of endocrine factors

KL Gamble, R Berry, SJ Frank, ME Young - Nature Reviews …, 2014 - nature.com
Organisms experience dramatic fluctuations in demands and stresses over the course of the
day. In order to maintain biological processes within physiological boundaries, mechanisms …

Signalling entrains the peripheral circadian clock

S Zhang, M Dai, X Wang, SH Jiang, LP Hu, XL Zhang… - Cellular signalling, 2020 - Elsevier
In mammals, 24-h rhythms of behaviour and physiology are regulated by the circadian clock.
The circadian clock is controlled by a central clock in the brain's suprachiasmatic nucleus …

Circadian rhythms in the hypothalamo–pituitary–adrenal (HPA) axis

A Kalsbeek, R Van der Spek, J Lei, E Endert… - Molecular and cellular …, 2012 - Elsevier
The pronounced daily variation in the release of adrenal hormones has been at the heart of
the deciphering and understanding of the circadian timing system. Indeed, the first …

[HTML][HTML] Mammalian molecular clocks

I Kwon, HK Choe, GH Son, K Kim - Experimental neurobiology, 2011 - ncbi.nlm.nih.gov
As a consequence of the Earth's rotation, almost all organisms experience day and night
cycles within a 24-hr period. To adapt and synchronize biological rhythms to external daily …

Coupled network of the circadian clocks: a driving force of rhythmic physiology

AM Finger, C Dibner, A Kramer - FEBS letters, 2020 - Wiley Online Library
The circadian system is composed of coupled endogenous oscillators that allow living
beings, including humans, to anticipate and adapt to daily changes in their environment. In …

Central circadian control of female reproductive function

BH Miller, JS Takahashi - Frontiers in endocrinology, 2014 - frontiersin.org
Over the past two decades, it has become clear just how much of our physiology is under the
control of the suprachiasmatic nucleus (SCN) and the cell-intrinsic molecular clock that ticks …

Circadian endocrine rhythms: the hypothalamic–pituitary–adrenal axis and its actions

NC Nicolaides, E Charmandari… - Annals of the new …, 2014 - Wiley Online Library
The stress system effectively restores the internal balance—or homeostasis—of living
organisms in the face of random external or internal changes, the stressors. This highly …