Chronopharmacological strategies focused on chrono-drug discovery
S Ohdo, S Koyanagi, N Matsunaga - Pharmacology & therapeutics, 2019 - Elsevier
In mammals, the circadian pacemaker resides in the paired suprachiasmatic nuclei (SCN)
and influences a multitude of biological processes, including the sleep–wake rhythm …
and influences a multitude of biological processes, including the sleep–wake rhythm …
The circadian rhythm of glucocorticoids is regulated by a gating mechanism residing in the adrenal cortical clock
H Oster, S Damerow, S Kiessling, V Jakubcakova… - Cell metabolism, 2006 - cell.com
In mammals, the master clock of the suprachiasmatic nuclei (SCN) and subordinate clocks
found throughout the body coordinate circadian rhythms of behavior and physiology. We …
found throughout the body coordinate circadian rhythms of behavior and physiology. We …
Challenging the omnipotence of the suprachiasmatic timekeeper: are circadian oscillators present throughout the mammalian brain?
C Guilding, HD Piggins - European Journal of Neuroscience, 2007 - Wiley Online Library
The suprachiasmatic nucleus of the hypothalamus (SCN) is the master circadian pacemaker
or clock in the mammalian brain. Canonical theory holds that the output from this single …
or clock in the mammalian brain. Canonical theory holds that the output from this single …
Circadian clock control of endocrine factors
Organisms experience dramatic fluctuations in demands and stresses over the course of the
day. In order to maintain biological processes within physiological boundaries, mechanisms …
day. In order to maintain biological processes within physiological boundaries, mechanisms …
Signalling entrains the peripheral circadian clock
In mammals, 24-h rhythms of behaviour and physiology are regulated by the circadian clock.
The circadian clock is controlled by a central clock in the brain's suprachiasmatic nucleus …
The circadian clock is controlled by a central clock in the brain's suprachiasmatic nucleus …
Circadian rhythms in the hypothalamo–pituitary–adrenal (HPA) axis
A Kalsbeek, R Van der Spek, J Lei, E Endert… - Molecular and cellular …, 2012 - Elsevier
The pronounced daily variation in the release of adrenal hormones has been at the heart of
the deciphering and understanding of the circadian timing system. Indeed, the first …
the deciphering and understanding of the circadian timing system. Indeed, the first …
[HTML][HTML] Mammalian molecular clocks
As a consequence of the Earth's rotation, almost all organisms experience day and night
cycles within a 24-hr period. To adapt and synchronize biological rhythms to external daily …
cycles within a 24-hr period. To adapt and synchronize biological rhythms to external daily …
Coupled network of the circadian clocks: a driving force of rhythmic physiology
The circadian system is composed of coupled endogenous oscillators that allow living
beings, including humans, to anticipate and adapt to daily changes in their environment. In …
beings, including humans, to anticipate and adapt to daily changes in their environment. In …
Central circadian control of female reproductive function
BH Miller, JS Takahashi - Frontiers in endocrinology, 2014 - frontiersin.org
Over the past two decades, it has become clear just how much of our physiology is under the
control of the suprachiasmatic nucleus (SCN) and the cell-intrinsic molecular clock that ticks …
control of the suprachiasmatic nucleus (SCN) and the cell-intrinsic molecular clock that ticks …
Circadian endocrine rhythms: the hypothalamic–pituitary–adrenal axis and its actions
NC Nicolaides, E Charmandari… - Annals of the new …, 2014 - Wiley Online Library
The stress system effectively restores the internal balance—or homeostasis—of living
organisms in the face of random external or internal changes, the stressors. This highly …
organisms in the face of random external or internal changes, the stressors. This highly …