Hypothalamic integration of central and peripheral clocks

RM Buijs, A Kalsbeek - Nature Reviews Neuroscience, 2001 - nature.com
During sleep, our biological clock prepares us for the forthcoming period of activity by
controlling the release of hormones and the activity of the autonomic nervous system. Here …

A clockwork web: circadian timing in brain and periphery, in health and disease

MH Hastings, AB Reddy, ES Maywood - Nature Reviews Neuroscience, 2003 - nature.com
Circadian rhythms are daily cycles of physiology and behaviour that are driven by an
endogenous oscillator with a period of approximately (circa-) one day (diem). Exemplified in …

Mammalian circadian networks mediated by the suprachiasmatic nucleus

Q Lu, JY Kim - The FEBS Journal, 2022 - Wiley Online Library
The brain has a complex structure composed of hundreds of regions, forming networks to
cooperate body functions. Therefore, understanding how various brain regions …

Circadian dysfunction in disease

DA Bechtold, JE Gibbs, ASI Loudon - Trends in pharmacological sciences, 2010 - cell.com
The classic view of circadian timing in mammals emphasizes a light-responsive 'master
clock'within the hypothalamus which imparts temporal information to the organism. Recent …

Minireview: entrainment of the suprachiasmatic clockwork in diurnal and nocturnal mammals

E Challet - Endocrinology, 2007 - academic.oup.com
Daily rhythmicity, including timing of wakefulness and hormone secretion, is mainly
controlled by a master clock located in the suprachiasmatic nucleus (SCN) of the …

Daily regulation of hormone profiles

A Kalsbeek, E Fliers - Circadian clocks, 2013 - Springer
The highly coordinated output of the hypothalamic biological clock does not only govern the
daily rhythm in sleep/wake (or feeding/fasting) behaviour but also has direct control over …

Circadian rhythm disturbances in mood disorders: insights into the role of the suprachiasmatic nucleus

CA Vadnie, CA McClung - Neural plasticity, 2017 - Wiley Online Library
Circadian rhythm disturbances are a common symptom among individuals with mood
disorders. The suprachiasmatic nucleus (SCN), in the ventral part of the anterior …

Invited review: a neural clockwork for encoding circadian time

ED Herzog, WJ Schwartz - Journal of Applied Physiology, 2002 - journals.physiology.org
10.1152/japplphysiol. 00836.2001.—Many daily biological rhythms are governed by an
innate timekeeping mechanism or clock. Endogenous, temperature-compensated circadian …

Mammalian circadian signaling networks and therapeutic targets

AC Liu, WG Lewis, SA Kay - Nature chemical biology, 2007 - nature.com
Virtually all cells in the body have an intracellular clockwork based on a negative feedback
mechanism. The circadian timekeeping system in mammals is a hierarchical multi-oscillator …

Entrainment of circadian clocks in mammals by arousal and food

RE Mistlberger, MC Antle - Essays in biochemistry, 2011 - portlandpress.com
Circadian rhythms in mammals are regulated by a system of endogenous circadian
oscillators (clock cells) in the brain and in most peripheral organs and tissues. One group of …