Circadian rhythms are an essential property of many living organisms, and arise from an
internal pacemaker, or clock. In mammals, this clock resides in the suprachiasmatic nucleus …

* Correspondence to: Ueli Schibler; Email: ueli. schibler@ unige. ch Submitted: 12/13/12;
Accepted: 01/09/13 http://dx. doi. org/10.4161/cc. 23670 Comment on: Morf J, Rey G, et al …

Circadian rhythms orchestrate biochemical and physiological processes in living organisms
to respond the day/night cycle. In mammals, nearly all cells hold self-sustained circadian …

The molecular circadian clock is a self-regulating transcription/translation cycle of positive
(Bmal1, Clock/Npas2) and negative (Per1, 2, 3, Cry1, 2) regulatory components. While the …

BACKGROUND Life-forms ranging from bacteria to humans are programmed by circadian
clocks—mechanisms that impose an~ 24-hour rhythmicity on biology in harmony with …

Most bodily functions vary over the course of a 24 h day. Circadian rhythms in body
temperature, sleep-wake cycles, metabolism, and blood pressure (BP) are just a few …

Obesity is a major risk factor for the development of illnesses, such as insulin resistance and
hypertension, and has become a serious public health problem. Mammals have developed …

In order for any organism to function properly, it is crucial that it be table to control the timing
of its biological functions. An internal biological clock, located, in mammals, in the …

Highlights•Clock gene expression solely in the suprachiasmatic nucleus (SCN) is sufficient
to drive circadian rhythms of physiology and behavior.•The output from the SCN is relayed …

The term “circadian rhythms” describes endogenous oscillations with ca. 24-h period
associated with the earth's daily rotation and light/dark cycle. Such rhythms reflect the …