The circadian clock and metabolic homeostasis: entangled networks

LVM de Assis, H Oster - Cellular and Molecular Life Sciences, 2021 - Springer
The circadian clock exerts an important role in systemic homeostasis as it acts a keeper of
time for the organism. The synchrony between the daily challenges imposed by the …

Circadian regulation of membrane physiology in neural oscillators throughout the brain

JR Paul, JA Davis, LK Goode, BK Becker… - European Journal of …, 2020 - Wiley Online Library
Twenty‐four‐hour rhythmicity in physiology and behavior are driven by changes in
neurophysiological activity that vary across the light–dark and rest‐activity cycle. Although …

The concept of coupling in the mammalian circadian clock network

V Pilorz, M Astiz, KO Heinen, O Rawashdeh… - Journal of molecular …, 2020 - Elsevier
The circadian clock network regulates daily rhythms in mammalian physiology and behavior
to optimally adapt the organism to the 24-h day/night cycle. A central pacemaker, the …

Circadian insights into dopamine mechanisms

J Mendoza, E Challet - Neuroscience, 2014 - Elsevier
Almost every physiological or behavioral process in mammals follows rhythmic patterns,
which depend mainly on a master circadian clock located in the hypothalamic …

Intercellular coupling between peripheral circadian oscillators by TGF-β signaling

AM Finger, S Jäschke, M Del Olmo, R Hurwitz… - Science …, 2021 - science.org
Coupling between cell-autonomous circadian oscillators is crucial to prevent
desynchronization of cellular networks and disruption of circadian tissue functions. While …

The arrival of circadian medicine

S Panda - Nature Reviews Endocrinology, 2019 - nature.com
Circadian rhythm research is beginning to show how rhythms sustain health. Genome-wide
transcriptome, metabolome and proteome studies have improved our understanding of …

Molecular components of the mammalian circadian clock

CH Ko, JS Takahashi - Human molecular genetics, 2006 - academic.oup.com
Circadian rhythms are∼ 24-h oscillations in behavior and physiology, which are internally
generated and function to anticipate the environmental changes associated with the solar …

Gestational chronodisruption impairs circadian physiology in rat male offspring, increasing the risk of chronic disease

N Mendez, D Halabi, C Spichiger, ER Salazar… - …, 2016 - academic.oup.com
Chronic exposure to light at night, as in shift work, alters biological clocks (chronodisruption),
negatively impacting pregnancy outcome in humans. Actually the interaction of maternal and …

Astrocytes sustain circadian oscillation and bidirectionally determine circadian period, but do not regulate circadian phase in the suprachiasmatic nucleus

AP Patton, NJ Smyllie, JE Chesham… - Journal of …, 2022 - Soc Neuroscience
The suprachiasmatic nucleus (SCN) is the master circadian clock of mammals, generating
and transmitting an internal representation of environmental time that is produced by the cell …

[HTML][HTML] Coordinated transcription of key pathways in the mouse by the circadian clock

S Panda, MP Antoch, BH Miller, AI Su, AB Schook… - Cell, 2002 - cell.com
In mammals, circadian control of physiology and behavior is driven by a master pacemaker
located in the suprachiasmatic nuclei (SCN) of the hypothalamus. We have used gene …