Gold Nanoparticles Inhibit VEGF165‐Induced Migration and Tube Formation of Endothelial Cells via the Akt Pathway

Y Pan, Q Wu, L Qin, J Cai, B Du - BioMed research international, 2014 - Wiley Online Library
The early stages of angiogenesis can be divided into three steps: endothelial cell
proliferation, migration, and tube formation. Vascular endothelial growth factor (VEGF) is …

Gold nanoparticles induce nanostructural reorganization of VEGFR2 to repress angiogenesis

Y Pan, H Ding, L Qin, X Zhao, J Cai… - Journal of biomedical …, 2013 - ingentaconnect.com
The inhibition of the binding between VEGFs and their receptors reduces angiogenesis and
retards tumor growth. Owing to the large amount of antibodies required, the antibody-based …

Inhibition effects of gold nanoparticles on proliferation and migration in hepatic carcinoma-conditioned HUVECs

Y Pan, Q Wu, R Liu, M Shao, J Pi, X Zhao… - Bioorganic & medicinal …, 2014 - Elsevier
Tumor angiogenesis is a complicated process based upon a sequence of interactions
between tumor and vessel endothelial cells. Tumor conditioned medium has been widely …

Retracted article: Gold nanoparticles inhibit vascular endothelial growth factor-induced angiogenesis and vascular permeability via src dependent pathway in retinal …

K Kalishwaralal, S Sheikpranbabu, S BarathManiKanth… - Angiogenesis, 2011 - Springer
The purpose of this study was to investigate the effect of gold nanoparticles on the signaling
cascade related to angiogenesis and vascular permeability induced by Vascular Endothelial …

Cellular localization and biological effects of 20nm‐gold nanoparticles

G Tan, MA Onur - … of Biomedical Materials Research Part A, 2018 - Wiley Online Library
Gold nanoparticles (AuNPs) have recently emerged as prominent vehicles for many
biomedical applications from sensing to delivery. The relevant literature contains conflicting …

Gold Nanoparticles Disrupt Tumor Microenvironment - Endothelial Cell Cross Talk To Inhibit Angiogenic Phenotypes in Vitro

Y Zhang, X Xiong, Y Huai, A Dey… - Bioconjugate …, 2019 - ACS Publications
It is currently recognized that perpetual cross talk among key players in tumor
microenvironment such as cancer cells (CCs), cancer associated fibroblasts (CAFs), and …

Gold nanoparticles and angiogenesis: molecular mechanisms and biomedical applications

RS Darweesh, NM Ayoub, S Nazzal - International journal of …, 2019 - Taylor & Francis
Angiogenesis is the formation of new blood vessels from pre-existing vessels. It is a highly
regulated process as determined by the interplay between pro-angiogenic and anti …

Gold nanoparticles induce tumor vessel normalization and impair metastasis by inhibiting endothelial Smad2/3 signaling

N Huang, Y Liu, Y Fang, S Zheng, J Wu, M Wang… - ACS …, 2020 - ACS Publications
Gold nanoparticles (AuNPs) are a promising nanomaterial due to their drug-delivery
properties and inherent anti-neoplastic activity. Here, we focused on the anti-neoplastic …

Gold nanoparticles induce heme oxygenase-1 expression through Nrf2 activation and Bach1 export in human vascular endothelial cells

TH Lai, JM Shieh, CJ Tsou, WB Wu - International journal of …, 2015 - Taylor & Francis
It has been reported that increased levels and activity of the heme oxygenase-1 (HO-1)
protein ameliorate tissue injuries. In the present study, we investigated the effects and …

Gold nanoparticles compromise TNF-α-induced endothelial cell adhesion molecule expression through NF-κB and protein degradation pathways and reduce …

TH Lai, CH Chung, BH Chen, CF Hung… - Journal of …, 2016 - ingentaconnect.com
The aim of this study was to investigate the anti-inflammatory effects and mechanism of
action of the gold nanoparticles (AuNPs) on vascular injury. In vitro vascular endothelial cell …