Historically, most pharmacological approaches to the treatment of addictive disorders have
utilized either substitution-based methods (ie, nicotine replacement or opioid maintenance) …

The past two decades have witnessed a dramatic accumulation of evidence indicating that
the excitatory amino acid glutamate plays an important role in drug addiction and …

Cortico-striatal glutamate transmission has been implicated in both the initiation and
expression of addiction related behaviors, such as locomotor sensitization and drug …

The AMPA antagonist, NBQX, produced dose-dependent blockade of the locomotor
stimulant effects of cocaine and methamphetamine in male, Swiss-Webster mice at doses …

Addiction is associated with neuroplasticity in the corticostriatal brain circuitry that is
important for guiding adaptive behaviour. The hierarchy of corticostriatal information …

Drug addiction has often been described as a “hijacking” of the brain circuits involved in
learning and memory. Glutamate is the principal excitatory neurotransmitter in the brain, and …

There is now compelling evidence that the excitatory amino acid neurotransmitter glutamate
plays a pivotal role in drug addiction and alcoholism. As a result, there has been increasing …

Results from preclinical rodent studies during the last 20 years implicated glutamate
neurotransmission in different brain regions in drug self-administration and rodent models of …

Considerable research into the neurobiology of cocaine addiction has shed light on the role
of glutamate. Findings from models of relapse to cocaine-seeking indicate that the …

Traditionally, addiction research in neuroscience has focused on mechanisms involving
dopamine and endogenous opioids. More recently, it has been realized that glutamate also …