Retinoid X receptor regulates Nur77/thyroid hormone receptor 3-dependent apoptosis by modulating its nuclear export and mitochondrial targeting
X Cao, W Liu, F Lin, H Li, SK Kolluri, B Lin… - … and Cellular Biology, 2004 - Am Soc Microbiol
Retinoid X receptor (RXR) plays a central role in the regulation of intracellular receptor
signaling pathways by acting as a ubiquitous heterodimerization partner of many nuclear …
signaling pathways by acting as a ubiquitous heterodimerization partner of many nuclear …
Retinoid X receptor regulates Nur77/TR3-dependent apoptosis [corrected] by modulating its nuclear export and mitochondrial targeting.
X Cao, W Liu, F Lin, H Li, SK Kolluri, B Lin… - … and cellular biology, 2004 - europepmc.org
Retinoid X receptor (RXR) plays a central role in the regulation of intracellular receptor
signaling pathways by acting as a ubiquitous heterodimerization partner of many nuclear …
signaling pathways by acting as a ubiquitous heterodimerization partner of many nuclear …
Overview of the structure-based non-genomic effects of the nuclear receptor RXRα
L Chen, L Wu, L Zhu, Y Zhao - Cellular & Molecular Biology Letters, 2018 - Springer
The nuclear receptor RXRα (retinoid X receptor-α) is a transcription factor that regulates the
expression of multiple genes. Its non-genomic function is largely related to its structure …
expression of multiple genes. Its non-genomic function is largely related to its structure …
Crosstalk between ERK2 and RXR regulates nuclear import of transcription factor NGFI-B
CM Jacobs, RE Paulsen - Biochemical and biophysical research …, 2005 - Elsevier
Transcription factor NGFI-B initiates apoptosis when allowed to translocate to mitochondria.
Retinoid-X receptor (RXR), another member of the nuclear receptor family, regulates NGFI-B …
Retinoid-X receptor (RXR), another member of the nuclear receptor family, regulates NGFI-B …
Retinoic acid and its receptors repress the expression and transactivation functions of Nur77: a possible mechanism for the inhibition of apoptosis by retinoic acid
HJ Kang, MR Song, SK Lee, EC Shin, YH Choi… - Experimental cell …, 2000 - Elsevier
Nur77 (NGFI-B) is an orphan nuclear receptor that has been implicated in activation-induced
T-cell apoptosis. Retinoids, potent immune modulators, were shown to inhibit the activation …
T-cell apoptosis. Retinoids, potent immune modulators, were shown to inhibit the activation …
Regulation of Nur77 nuclear export by c-Jun N-terminal kinase and Akt
YH Han, X Cao, B Lin, F Lin, SK Kolluri, J Stebbins… - Oncogene, 2006 - nature.com
Proapoptotic nuclear receptor family member Nur77 translocates from the nucleus to the
mitochondria, where it interacts with Bcl-2 to trigger apoptosis. Nur77 translocation is …
mitochondria, where it interacts with Bcl-2 to trigger apoptosis. Nur77 translocation is …
Rapid apoptosis induction by IGFBP-3 involves an insulin-like growth factor-independent nucleomitochondrial translocation of RXRα/Nur77
KW Lee, L Ma, X Yan, B Liu, X Zhang… - Journal of Biological …, 2005 - ASBMB
Insulin-like growth factor-binding protein-3 (IGFBP-3) induces apoptosis by its ability to bind
insulin-like growth factors (IGFs) as well as its IGF-independent effects involving binding to …
insulin-like growth factors (IGFs) as well as its IGF-independent effects involving binding to …
RXRα acts as a carrier for TR3 nuclear export in a 9-cis retinoic acid-dependent manner in gastric cancer cells
XF Lin, BX Zhao, HZ Chen, XF Ye… - Journal of cell …, 2004 - journals.biologists.com
Retinoid X receptor (RXR) plays a crucial role in the cross talk between retinoid receptors
and other hormone receptors including the orphan receptor TR3, forming different …
and other hormone receptors including the orphan receptor TR3, forming different …
Modulation of retinoid signalling through NGF-induced nuclear export of NGFI-B
Y Katagiri, K Takeda, ZX Yu, VJ Ferrans, K Ozato… - Nature cell …, 2000 - nature.com
The retinoid–X receptor (RXR) regulates multiple hormonal pathways through
heterodimerization with nuclear receptors such as the all-trans retinoic acid receptor (RAR) …
heterodimerization with nuclear receptors such as the all-trans retinoic acid receptor (RAR) …
Targeting nur77 translocation
X Zhang - Expert opinion on therapeutic targets, 2007 - Taylor & Francis
The ultimate growth of a tumour depends on not only the rate of tumour cell proliferation, but
also the rate of tumour cell death (apoptosis). Nur77 (also known as TR3 or NGFI-B), an …
also the rate of tumour cell death (apoptosis). Nur77 (also known as TR3 or NGFI-B), an …