▪ Abstract Synaptic vesicle exocytosis occurs in consecutive steps: docking, which
specifically attaches vesicles to the active zone; priming, which makes the vesicles …

During an action potential, Ca 2+ entering a presynaptic terminal triggers synaptic vesicle
exocytosis and neurotransmitter release in less than a millisecond. How does Ca 2+ …

Calcium (Ca2+)-evoked release of neurotransmitters from synaptic vesicles requires
mechanisms both to prevent un-initiated fusion of vesicles (clamping) and to trigger fusion …

Background In neurons, release of neurotransmitter occurs through the fusion of synaptic
vesicles with the plasma membrane. Many proteins required for this process have been …

In neurons, depolarization induces Ca2+ influx leading to fusion of synaptic vesicles docked
at the active zone for neurotransmitter release. While a number of proteins have now been …

Ca 2+ binding to synaptotagmin 1 triggers fast exocytosis of synaptic vesicles that have
been primed for release by SNARE-complex assembly. Besides synaptotagmin 1, fast Ca 2+ …

Synaptic vesicle fusion is catalyzed by assembly of synaptic SNARE complexes, and is
regulated by the synaptic vesicle GTP‐binding protein Rab3 that binds to RIM and to …

SNARE proteins and synaptotagmin are key components of the complex machinery that
controls Ca 2+-triggered neurotransmitter release but their mechanisms of action are under …

Chemical SYNAPTIC transmission depends upon Ca'+-triggered exocytosis of
neurotransmitters from presynaptic terminals. Neurotransmitters are sequestered actively …

Synaptotagmins contain tandem C2 domains and function as Ca2+ sensors for vesicle
exocytosis but the mechanism for coupling Ca2+ rises to membrane fusion remains …