[HTML][HTML] Ginsenoside compound K reduces the progression of Huntington's disease via the inhibition of oxidative stress and overactivation of the ATM/AMPK pathway

KF Hua, AC Chao, TY Lin, WT Chen, YC Lee… - Journal of Ginseng …, 2022 - Elsevier
Background Huntington's disease (HD) is a neurodegenerative disorder caused by the
expansion of trinucleotide CAG repeat in the Huntingtin (Htt) gene. The major pathogenic …

Therapeutic potential of ginsenoside Rg3 and Rf for Huntington's disease

M Lee, JJ Ban, BH Won, W Im, M Kim - In Vitro Cellular & Developmental …, 2021 - Springer
Ginseng is a popular herbal medicine and known to have protective and therapeutic effects
in various diseases. Ginsenosides are active gradients representing the diverse …

Ginsenoside Rg1 exerts neuroprotective effects in 3-nitropronpionic acid-induced mouse model of Huntington's disease via suppressing MAPKs and NF-κB pathways …

X Yang, S Chu, Z Wang, F Li, Y Yuan… - Acta Pharmacologica …, 2021 - nature.com
Huntington's disease (HD) is one of main neurodegenerative diseases, characterized by
striatal atrophy, involuntary movements, and motor incoordination. Ginsenoside Rg1 (Rg1) …

Gintonin, a ginseng-derived ingredient, as a novel therapeutic strategy for Huntington's disease: Activation of the Nrf2 pathway through lysophosphatidic acid …

M Jang, JH Choi, Y Chang, SJ Lee, SY Nah… - Brain, Behavior, and …, 2019 - Elsevier
Abstract Gintonin (GT), a ginseng-derived lysophosphatidic acid receptor ligand, regulates
various cellular effects and represses inflammation. However, little is known about the …

Glycyrrhizin prevents 3-nitropropionic acid-induced neurotoxicity by downregulating HMGB1/TLR4/NF-κB p65 signaling, and attenuating oxidative stress, inflammation …

AM Gendy, HM El-Sadek, MM Amin, KA Ahmed… - Life Sciences, 2023 - Elsevier
Abstract Aims Glycyrrhizin (Glyc) is a saponin triterpenoid that has signified its efficacy
against Huntington's disease (HD). Nonetheless, its mechanism has not been fully clarified …

Ginsenosides protect striatal neurons in a cellular model of Huntington's disease

J Wu, HK Jeong, SE Bulin, SW Kwon… - Journal of …, 2009 - Wiley Online Library
Ginseng, the root of Panax ginseng CA Meyer (Araliaceae), is a widely used herbal
medicine. Ginsenosides, the active ingredients of ginseng, are the main components …

CGS21680 attenuates symptoms of Huntington's disease in a transgenic mouse model

SY Chou, YC Lee, HM Chen, MC Chiang… - Journal of …, 2005 - Wiley Online Library
Huntington's disease (HD) is an autosomal dominant neurodegenerative disease caused by
a CAG trinucleotide expansion in exon 1 of the Huntingtin (Htt) gene. We show herein that in …

Treatment with a herbal formula B401 enhances neuroprotection and angiogenesis in the R6/2 mouse model of Huntington's disease

SE Wang, CL Lin, CH Hsu, SJ Sheu… - Drug Design …, 2015 - Taylor & Francis
Huntington's disease (HD) is a neurodegenerative disease characterized by motor
dysfunction and early death. Despite years of research, the mechanisms responsible for …

Korean Red Ginseng Extract Attenuates 3‐Nitropropionic Acid‐Induced Huntington's‐Like Symptoms

M Jang, MJ Lee, CS Kim, IH Cho - … ‐Based Complementary and …, 2013 - Wiley Online Library
Korean red ginseng (KRG) possesses neuroprotective activity. However, the potential
neuroprotective value of KRG for the striatal toxicity is largely unknown. We investigated …

Ginsenoside Re and Rd enhance the expression of cholinergic markers and neuronal differentiation in Neuro-2a cells

MS Kim, JM Yu, HJ Kim, HB Kim, ST Kim… - Biological and …, 2014 - jstage.jst.go.jp
In Alzheimer's disease (AD), extensive neuronal loss and a deficiency of the
neurotransmitter acetylcholine (ACh) are the major characteristics during pathogenesis in …