Genetic background shapes phenotypic response to diet for adiposity in the collaborative cross
P Yam, J Albright, M VerHague, ER Gertz… - Frontiers in …, 2021 - frontiersin.org
Defined as chronic excessive accumulation of adiposity, obesity results from long-term
imbalance between energy intake and expenditure. The mechanisms behind how caloric …
imbalance between energy intake and expenditure. The mechanisms behind how caloric …
Altered macronutrient composition and genetics influence the complex transcriptional network associated with adiposity in the Collaborative Cross
P Yam, M VerHague, J Albright, E Gertz… - Genes & Nutrition, 2022 - Springer
Background Obesity is a serious disease with a complex etiology characterized by
overaccumulation of adiposity resulting in detrimental health outcomes. Given the liver's …
overaccumulation of adiposity resulting in detrimental health outcomes. Given the liver's …
[HTML][HTML] Synergizing mouse and human studies to understand the heterogeneity of obesity
Obesity is routinely considered as a single disease state, which drives a “one-size-fits-all”
approach to treatment. We recently convened the first annual University of North Carolina …
approach to treatment. We recently convened the first annual University of North Carolina …
Divergent physical activity and novel alternative responses to high fat feeding in polygenic fat and lean mice
We determined whether altered physical activity levels might underlie the contrasting
adiposity of a divergently selected polygenic murine model of metabolic syndrome (Fat; F) …
adiposity of a divergently selected polygenic murine model of metabolic syndrome (Fat; F) …
Genetic variation and correlation of dietary response in an advanced intercross mouse line produced from two divergent growth lines
TH Ehrich, JP Kenney-Hunt, LS Pletscher… - Genetics …, 2005 - cambridge.org
Levels of human obesity have increased over the past 20 years worldwide, primarily due to
changes in diet and activity levels. Although environmental changes are clearly responsible …
changes in diet and activity levels. Although environmental changes are clearly responsible …
Increased variation in body weight and food intake is related to increased dietary fat but not increased carbohydrate or protein in mice
A variety of inbred mouse strains have been used for research in metabolic disorders.
Despite being inbred, they display large inter-individual variability for many traits like food …
Despite being inbred, they display large inter-individual variability for many traits like food …
Genetic determinants of atherosclerosis, obesity, and energy balance in consomic mice
SH Spiezio, LM Amon, TS McMillen, CM Vick… - Mammalian …, 2014 - Springer
Metabolic diseases such as obesity and atherosclerosis result from complex interactions
between environmental factors and genetic variants. A panel of chromosome substitution …
between environmental factors and genetic variants. A panel of chromosome substitution …
Advances in comparative genetics: influence of genetics on obesity
Obesity has reached epidemic proportions and is recognised as a significant global health
problem. Increased food intake and decreased physical activity are traditionally to blame for …
problem. Increased food intake and decreased physical activity are traditionally to blame for …
Complex genetics of obesity in mouse models
D Pomp, D Nehrenberg, D Estrada-Smith - Annu. Rev. Nutr., 2008 - annualreviews.org
Traits related to energy balance and obesity are exceptionally complex, with varying
contributions of genetic susceptibility and interacting environmental factors. The use of …
contributions of genetic susceptibility and interacting environmental factors. The use of …
Genetic background and sex control the outcome of high-fat diet feeding in mice
AM Bachmann, JD Morel, G El Alam… - IScience, 2022 - cell.com
The sharp increase in obesity prevalence worldwide is mainly attributable to changes in
physical activity and eating behavior but the metabolic and clinical impacts of these …
physical activity and eating behavior but the metabolic and clinical impacts of these …