Defined as chronic excessive accumulation of adiposity, obesity results from long-term
imbalance between energy intake and expenditure. The mechanisms behind how caloric …

Background Obesity is a serious disease with a complex etiology characterized by
overaccumulation of adiposity resulting in detrimental health outcomes. Given the liver's …

Obesity is routinely considered as a single disease state, which drives a “one-size-fits-all”
approach to treatment. We recently convened the first annual University of North Carolina …

We determined whether altered physical activity levels might underlie the contrasting
adiposity of a divergently selected polygenic murine model of metabolic syndrome (Fat; F) …

Levels of human obesity have increased over the past 20 years worldwide, primarily due to
changes in diet and activity levels. Although environmental changes are clearly responsible …

A variety of inbred mouse strains have been used for research in metabolic disorders.
Despite being inbred, they display large inter-individual variability for many traits like food …

Metabolic diseases such as obesity and atherosclerosis result from complex interactions
between environmental factors and genetic variants. A panel of chromosome substitution …

Obesity has reached epidemic proportions and is recognised as a significant global health
problem. Increased food intake and decreased physical activity are traditionally to blame for …

Traits related to energy balance and obesity are exceptionally complex, with varying
contributions of genetic susceptibility and interacting environmental factors. The use of …

The sharp increase in obesity prevalence worldwide is mainly attributable to changes in
physical activity and eating behavior but the metabolic and clinical impacts of these …