Experimental autoimmune encephalomyelitis (EAE) is an inflammatory disease of the CNS,
which has long been used as an animal model for human multiple sclerosis. Development of …

NF-κB is an inducible transcription factor involved in the induction of multiple genes during
inflammatory processes. So far the information pertaining to the role of NF-κB in autoimmune …

Abstract The NF-κB/REL-family of transcription factors plays a central role in coordinating the
expression of a wide variety of genes controlling immune responses including autoimmunity …

NF-κB is a key player in inflammatory diseases, including multiple sclerosis (MS) and its
animal model, experimental autoimmune encephalomyelitis (EAE). However, the effects of …

The transcription factor nuclear factor κB (NF-κB) plays major roles in inflammatory diseases
through regulation of inflammation and cell viability. Multiple sclerosis (MS) is a chronic …

The noncanonical NF-κB pathway induces processing of the NF-κB2 precursor protein p100,
and thereby mediates activation of p52-containing NF-κB complexes. This pathway is crucial …

In the CNS, the transcription factor NF-κB is a key regulator of inflammation and secondary
injury processes. Following trauma or disease, the expression of NF-κB-dependent genes is …

Activation of transcription factor NF-κB in the central nervous system (CNS) has been linked
to autoimmune demyelinating disease; however, it remains unclear whether its function is …

In this report, we establish a regulatory role of natural killer (NK) cells in experimental
autoimmune encephalomyelitis (EAE), a prototype T helper cell type 1 (Th1)-mediated …

The NF-κB family of transcription factors plays a pivotal role in T cell activation and survival
during (auto) immune responses. IκB kinase 2/β (IKK2) is part of the IκB kinase complex, a …