Preclinical research findings in laboratory animals indicate that the glutamatergic system is
critically involved in nicotine dependence. In animals, compounds that decrease …

Nicotine dependence is the primary motivational factor perpetuating the tobacco smoking
habit that is one of the leading preventable causes of morbidity throughout the world. This …

Tobacco smoking continues to be a major global health hazard despite significant public
awareness of its harmful consequences. Although several treatment options are currently …

Nicotine plays an important role in the initiation and maintenance of tobacco smoking.
Importantly, chronic nicotine exposure alters the function of brain reward systems, resulting …

Tobacco smoking causes high rates of mortality and morbidity throughout the world. Despite
the availability of smoking-cessation medications, maintenance of long-term abstinence is …

Glutamate neurotransmission, and particularly metabotropic glutamate (mGlu) 2/3 receptors
are implicated in behaviors of relevance to the addictive properties of nicotine. In laboratory …

Rationale Numerous medication development strategies seek to decrease nicotine
consumption and prevent relapse to tobacco smoking by blocking glutamate transmission …

Nicotine is a psychoactive ingredient in tobacco that significantly contributes to the harmful
tobacco smoking habit. Nicotine dependence is more prevalent than dependence on any …

Previous work indicated a role for GABA and glutamate in the reinforcing effects of drugs of
abuse. The present studies assessed the effects of GABAergic and glutamatergic …

Nicotine abuse and addiction is a major health liability. Nicotine, an active alkaloid in
tobacco, is self-administered by animals and produces cellular adaptations in brain regions …