Previous studies suggested that metabotropic glutamate 5 (mGlu5) receptors play an
important role in the reinforcing effects of abused drugs. The present experiments evaluated …

This review focuses on a specific interaction occurring between the nicotinic cholinergic
receptors (nAChRs) and the glutamatergic receptors (GluRs) at the nerve endings level. We …

Nicotine self‐administration causes adaptation in the mesocorticolimbic glutamatergic
system, including the up‐regulation of ionotropic glutamate receptor subunits. We therefore …

Neuronal nicotinic acetylcholine receptors (nAChRs) regulate the rewarding actions of
nicotine contained in tobacco that establish and maintain the smoking habit. nAChRs also …

Diseases associated with tobacco use constitute a major health problem worldwide. Upon
cessation of tobacco use, an unpleasant withdrawal syndrome occurs in dependent …

Introduction: Increasing evidence indicates a crucial role of glutamate in the brain reward
system and nicotine addiction. Because the pertinent models involve frontal and …

Current smoking cessation pharmacotherapies have limited efficacy in preventing relapse
and maintaining abstinence during withdrawal. Galantamine is an acetylcholinesterase …

Abstract The metabotropic glutamate 2/3 (mGlu2/3) receptor agonist LY379268 ([−]-2-oxa-4-
aminobicyclo [3.1. 0] hexane-4, 6-dicarboxylate) attenuates both nicotine self-administration …

Understanding the basic and clinical pharmacology of nicotine provides a basis for
improved prevention and treatment of tobacco addiction. Nicotine acts on nicotinic …

Nicotine dependence is a disease of constantly growing importance. This mini-review
describes the effects of nicotine in humans and focuses on the various laboratory animal …