Introduction: Tobacco use is strongly driven by the pharmacological actions of nicotine in the
central nervous system. This review will summarize some of the seminal research findings …

The paradoxical status of the pharmacology of nicotinic mechanisms as a research problem
has both stimulated and frustrated psychopharmacologists. The paradox is the dissonance …

Although the addictive influence of tobacco was recognized very early, the modern concepts
of nicotine addiction have relied on knowledge of cholinergic neurotransmission and …

Compounds that modulate metabotropic glutamate subtype 2 (mGlu2) receptors have the
potential to treat several disorders of the central nervous system (CNS) including drug …

Despite decades of research and anti-tobacco messaging, nicotine addiction remains an
important public health problem leading to hundreds of thousands of deaths each year …

Nicotine, the addictive component of cigarette smoke has profound effects on the brain.
Activation of its receptors by nicotine has complex consequences for network activity …

Nicotine sustains tobacco addiction, a major cause of disability and premature death.
Nicotine binds to nicotinic cholinergic receptors, facilitating neurotransmitter release and …

Analgesic tolerance is partially mediated by enhanced glutamatergic transmission in the
CNS. β-lactam antibiotics, through glutamate transporter subtype 1 (GLT-1) activation …

Tobacco use is a form of drug dependence, pharmacologically mediated by the actions of
nicotine at central and peripheral receptors. Nonpharmacological factors are also important …

BACKGROUND: The present study determined if, akin to cocaine, nicotine self-
administration in rats induces adaptations in the expression of glutamate transporters and …