MATERIALSAND METHODS Carrier-free 67Ga-citrate was purchased from Medi-Physics,
Chicago, IL. Iodine-l31 (ICN Radiochemicals, Irvine, CA) was labeled to human serum …

MATERIALS AND METHODS Human apotransferrin, human ai acid glycoprotein
(orosomucoid) and neuraminidase (from Clostridium perfringens, type VI-A, EC 3.2. l. 18) …

DISCUSSION To correlate the role of TF in 67Galocalization with scintigrams and actual
tissue concentration, it is necessary to determine the percentage ofthe main nonprotein …

When injected at tracer levels into the blood, radiogallium as 67 Ga-citrate binds to, and is
transported to the site of the tumor by, transferrin. The process by which transferrin-bound …

If iv injected radiogallium does not firmly bind to circulating transferrin in plasma, the
transvascular transport of the radionuclide may be affected by diffusion of unbound …

IT IS now well established that unless administered into plasma or serum environments in a
very stable chemical form such as the EDTA or DTPA chelate, gallium is rapidly and …

METhODS Indium-I11 or †7Gabindingto HoFE To examinethe influenceof ATP and PP@
on 67Gabinding to HoFF, an aliquot of a stock 10-mM ATP, PP1, or buffer solution was …

DISCUSSION Although poorly understood in the past, much has been learned about the
metabolism of gallium and similar ions in recent years (5— 12). Studieshave shown that …

Labeling of plasma transferrin with gallium was investigated to determine whether the
gallium-transferrin complex could be effectively used as a macromolecular tracer in studies …

When injected at tracer levels into the blood, radiogallium binds to plasma transferrin and is
transported to the tumor tissue. The mechanism, however, by which this transferrin-bound …