The formalin test is the most widely used behavioral screening test for analgesic
compounds. The cellular mechanism of action of formaldehyde, inducing a typically biphasic …

The formalin test still surprises with its biphasic pain-related behavior resulting from a
quiescent interphase that does not occur with other algogenic compounds and remains …

The most widely used formalin test to screen antinociceptive drug candidates is still
apostrophized as targeting inflammatory pain, in spite of strong opposing evidence …

The formalin model is widely used for evaluating the effects of analgesic compounds in
laboratory animals. Injection of formalin into the hind paw induces a biphasic pain response; …

Tissue damage and its downstream consequences are experimentally assayed by
formaldehyde application, which indiscriminately modifies proteins and is presumed to …

The letter by Fischer et al., published in this issue of Neuroscience, is well written and
logical. However, I believe this letter is fighting a paper tiger. The conflict between the …

The formalin test is a commonly used animal model of acute and tonic pain. However, the
molecular targets of formaldehyde (FA, the main ingredient of the formalin solution) on …

TRPA1 is an excitatory ion channel expressed by a subpopulation of primary afferent
somatosensory neurons that contain substance P and calcitonin gene-related peptide …

Formalin-evoked trigeminal pain behavior depends on TRPV4 calcium-permeable
channels, also on MEK-ERK signaling in trigeminal ganglion neurons. ABSTRACT …

Six transient receptor potential (TRP) ion channels expressed in the sensory afferents play
an important role as body thermosensors and also as peripheral pain detectors. It is known …