Optimized glucocorticoid therapy: teaching old drugs new tricks

C Strehl, F Buttgereit - Molecular and cellular endocrinology, 2013 - Elsevier
Glucocorticoids (GCs) are commonly used in the treatment of a wide range of rheumatic and
other inflammatory diseases. They exert their potent anti-inflammatory and …

[PDF][PDF] Pharmacodynamics of glucocorticoids

C Strehl, CM Spies, F Buttgereit - Clinical and Experimental …, 2011 - clinexprheumatol.org
Exogenous glucocorticoids (GCs) are used as anti-inflammatory and immunosuppressive
drugs in the treatment of a wide range of rheumatic and other inflammatory diseases. GCs …

Glucocorticoids' pharmacology: past, present and future

S Gessi, S Merighi… - Current pharmaceutical …, 2010 - ingentaconnect.com
Glucocorticoids (GCs) constitute the most important and widely prescribed class of anti-
inflammatory and immunosuppressive drugs. Since their first clinical use more than half a …

Therapeutic mechanisms of glucocorticoids

J Vandewalle, A Luypaert, K De Bosscher… - Trends in Endocrinology & …, 2018 - cell.com
Glucocorticoids (GCs) have been used clinically for decades as potent anti-inflammatory
and immunosuppressive agents. Nevertheless, their use is severely hampered by the risk of …

Molecular mechanisms of glucocorticoid action and selective glucocorticoid receptor agonists

C Stahn, M Löwenberg, DW Hommes… - Molecular and cellular …, 2007 - Elsevier
Glucocorticoids (GC) are the most common used anti-inflammatory and immunosuppressive
drugs in the treatment of rheumatic and other inflammatory diseases. Their therapeutic …

Minireview: latest perspectives on antiinflammatory actions of glucocorticoids

K De Bosscher, G Haegeman - Molecular endocrinology, 2009 - academic.oup.com
Taking into consideration that glucocorticoid (GC) hormones have been used clinically for
over half a century and that more than 20 yr have passed since the cloning of the GC …

[PDF][PDF] Novel glucocorticoids: where are we now and where do we want to go

F Buttgereit, CM Spies, JW Bijlsma - Clin Exp Rheumatol, 2015 - clinexprheumatol.org
Glucocorticoid (GC) therapy is widely accepted as effective treatment for many inflammatory
conditions. However, the potential of GC to produce adverse effects may prompt both …

Unraveling the functions of the membrane‐bound glucocorticoid receptors: first clues on origin and functional activity

C Strehl, F Buttgereit - Annals of the New York Academy of …, 2014 - Wiley Online Library
Glucocorticoids (GCs) are routinely used to treat a wide range of rheumatic and other
inflammatory diseases. GCs are steroidal drugs that exert their strong anti‐inflammatory and …

The search for safer glucocorticoid receptor ligands

J Rosen, JN Miner - Endocrine reviews, 2005 - academic.oup.com
Steroidal glucocorticoids are commonly used due to their powerful antiinflammatory activity.
However, despite their excellent efficacy, severe side effects frequently limit the use of these …

Defining the role of glucocorticoids in inflammation

S Ronchetti, G Migliorati, S Bruscoli… - Clinical Science, 2018 - portlandpress.com
An established body of knowledge and clinical practice has argued in favor of the use of
glucocorticoids in various chronic inflammatory and autoimmune diseases. However, the …