Emerging evidence indicates that many aspects of alcohol and drug dependence involve
changes in glutamate transmission. A number of studies have reported that drugs of abuse …

The development of new treatments for substance use disorders requires identification of
targetable molecular mechanisms. Pathology in glutamatergic neurotransmission system in …

Drug addiction has often been described as a “hijacking” of the brain circuits involved in
learning and memory. Glutamate is the principal excitatory neurotransmitter in the brain, and …

Alcoholism is a serious public health concern that is characterized by the development of
tolerance to alcohol's effects, increased consumption, loss of control over drinking and the …

Methamphetamine (METH) is one of the psychostimulants that is co-abused with ethanol.
Repeated exposure to high dose of METH has been shown to cause increases in …

Abstract l-Glutamate is the predominant excitatory neurotransmitter in the central nervous
system (CNS) and is directly and indirectly involved in a variety of brain functions. Glutamate …

Alteration of glutamatergic-neurotransmission is a hallmark of alcohol dependence. We
have previously reported that chronic ethanol-drinking downregulated glutamate transporter …

Potential therapeutic role of glutamate transporter 1 for the treatment of alcohol dependence -
PMC Back to Top Skip to main content NIH NLM Logo Access keys NCBI Homepage MyNCBI …

Rationale An increasingly compelling literature points to a major role for the glutamate
system in mediating the effects of alcohol on behavior and the pathophysiology of …

The β-lactam antibiotic ceftriaxone (CTX) reduces cocaine reinforcement and relapse in
preclinical assays through a mechanism involving activation of glutamate transporter …