The human T-cell leukemia virus type-2 (HTLV-2) integrase (IN) catalyzes the insertion of
the viral genome into the host chromosome. HTLV-2 IN was expressed as an N-terminal …

The C‐terminal part of the pol gene of the human T‐cell leukemia virus type I (HTLV‐I) is
predicted to encode the integrase (IN) of the virus; however, this protein has not yet been …

Despite the widespread nature of HTLV-II in New World populations and intravenous drug
users, the enzymatic activities of thepolgenes have not been reported. To ascertain the …

X-ray diffraction data on a few retroviral integrases show a flexible loop near the active site.
By sequence alignment, the peptide region 207–218 of Mo-MLV IN appears to correspond …

We cloned a human endogenous retrovirus K1O DNA fragment encoding integrase and
expressed it as a fusion protein with Escherichia coli maltose-binding protein. Integrase …

The retroviral integrase (IN) carries out the integration of viral DNA into the host genome.
The IN protein consists of three domains: the N-terminal HHCC motif, the catalytic core …

Retroviral integrases (INs) interact with termini of retroviral DNA in the conserved 5′-C
(A/G) T. For most integrases, modifications of critical moieties in the major and minor …

Retroviral integrases perform two catalytic steps, 3'processing and strand transfer, that result
in the stable insertion of the retroviral DNA into the host genome. Mutant M-MuLV integrases …

The forward and reverse reactions for integration were characterized for the Moloney murine
leukemia virus integrase (M-MuLV IN) protein. The M-MuLV IN was recombinantly produced …

Retroviral integration involves two DNA substrates that play different roles. The viral DNA
substrate is recognized by virtue of specific nucleotide sequences near the end of a double …