To evaluate the effect of different initial levothyroxine (LT4) replacement doses on growth
and intellectual outcome in patients with congenital hypothyroidism (CH) detected by …

Background and aims: The optimal dose of thyroxine (T4) in congenital hypothyroidism (CH)
during infancy is controversial. Higher doses lead to improvement in cognitive scores, but …

Objective: To determine between timing and LT4 dose which was the more important factor
for IQ at 7 years in screened congenital hypothyroidism (CH). Methods: 131 children with CH …

Objectives: To test whether early treatment with a high initial dose of levothyroxine can
prevent suboptimal mental development in all neonates with congenital hypothyroidism …

The appropriateness of the recommended L-thyroxine dose (10-15 μg/kg/day) for the
treatment of congenital hypothyroidism has been questioned because of the risk of …

The purpose of this study was to assess how much of the variance in intellectual outcome at
2 and 6 years of age could be attributed to treatment variables in children with congenital …

We have previously reported that despite neonatal screening, children with severe
congenital hypothyroidism treated at 5 weeks of age with 6 micrograms/kg. day …

Neonatal screening programs for congenital hypothyroidism (CH) were initiated in the 1970s
to ensure early treatment in order to prevent mental retardation. With screening …

Context The optimal levothyroxine (LT4) dose to treat congenital hypothyroidism (CH)
remains unclear, with debate over whether higher starting doses (> 10 µg/kg) are necessary …

Aims: To evaluate therapy and dose adjustments in patients with congenital hypothyroidism
(CH), longitudinally followed up until 16 years old, according to aetiology, Beclard's nuclei …