Corilagin alleviates acetaminophen-induced hepatotoxicity via enhancing the AMPK/GSK3β-Nrf2 signaling pathway

H Lv, L Hong, Y Tian, C Yin, C Zhu, H Feng - Cell communication and …, 2019 - Springer
Background Acetaminophen (APAP) overdose-induced acute liver failure (ALF) is mainly
resulted from uncontrolled oxidative stress. Nuclear factor-erythroid 2-related factor 2 (Nrf2) …

[HTML][HTML] Corilagin reduces acetaminophen-induced hepatotoxicity through MAPK and NF-κB signaling pathway in a mouse model

FC Liu, HP Yu, AH Chou, HC Lee… - American Journal of …, 2020 - ncbi.nlm.nih.gov
Corilagin is a major active polyphenolic tannins extracted from Phyllanthus urinaria, an
important herb used in traditional medicine. Previous reports demonstrated that corilagin …

Role of NADPH Oxidase-Derived ROS-Mediated IL-6/STAT3 and MAPK/NF-κB Signaling Pathways in Protective Effect of Corilagin against Acetaminophen-Induced …

FC Liu, HC Lee, CC Liao, AH Chou, HP Yu - Biology, 2023 - mdpi.com
Simple Summary Acetaminophen overdose causes acute liver injury by excessive oxidative
stress. The present study examines the mechanisms underlying the protective effect of …

Naringin alleviates a cetaminophen‐induced acute liver injury by activating Nrf2 via CHAC2 upregulation

X Zhai, T Dai, Z Chi, Z Zhao, G Wu… - Environmental …, 2022 - Wiley Online Library
Severe acetaminophen (APAP)‐induced hepatic damage is the second most common
cause for hepatic transplantation. Clinically, hepatic damage caused by APAP is treated …

Licochalcone A upregulates Nrf2 antioxidant pathway and thereby alleviates acetaminophen-induced hepatotoxicity

H Lv, Q Xiao, J Zhou, H Feng, G Liu, X Ci - Frontiers in Pharmacology, 2018 - frontiersin.org
Acetaminophen (APAP) overdose-induced fatal hepatotoxicity is majorly characterized by
overwhelmingly increased oxidative stress while enhanced nuclear factor-erythroid 2 …

Shikonin attenuates acetaminophen-induced hepatotoxicity by upregulation of Nrf2 through Akt/GSK3β signaling

H Li, Y Chen, J Zhang, X Chen, Z Li, B Liu, L Zhang - Molecules, 2018 - mdpi.com
Acetaminophen (APAP) overdose-induced acute liver damage is mostly due to
overwhelmingly increased oxidative stress. Nuclear factor-erythroid 2-related factor2 (Nrf2) …

γ-Oryzanol alleviates acetaminophen-induced liver injury: roles of modulating AMPK/GSK3β/Nrf2 and NF-κB signaling pathways

G Shu, Y Qiu, J Hao, Q Fu, X Deng - Food & function, 2019 - pubs.rsc.org
Acetaminophen (APAP) overdose is a major cause of drug-induced liver injury worldwide.
Our current study was performed to assess the potential protective effects of γ-oryzanol …

Isoorientin ameliorates APAP-induced hepatotoxicity via activation Nrf2 antioxidative pathway: The involvement of AMPK/Akt/GSK3β

X Fan, H Lv, L Wang, X Deng, X Ci - Frontiers in pharmacology, 2018 - frontiersin.org
Oxidative stress has been highlighted as therapeutic targets for acetaminophen (APAP)-
induced hepatotoxicity. Isoorientin (Iso), a well-known flavonoid-like compound, has been …

Astragaloside IV attenuates acetaminophen-induced liver injuries in mice by activating the Nrf2 signaling pathway

L Li, W Huang, S Wang, K Sun, W Zhang, Y Ding… - Molecules, 2018 - mdpi.com
Acetaminophen (APAP) is a well-known antipyretic and analgesic drug. However, the
accidental or intentional APAP overdose will induce liver injury and even acute liver failure …

Natural polyphenol chlorogenic acid protects against acetaminophen-induced hepatotoxicity by activating ERK/Nrf2 antioxidative pathway

M Wei, Z Zheng, L Shi, Y Jin, L Ji - Toxicological Sciences, 2018 - academic.oup.com
Hepatotoxicity due to acetaminophen (APAP) overdose is a leading cause of drug-induced
acute liver failure in clinic. Chlorogenic acid (CGA), a dietary polyphenol, was reported to …