Purpose. Islet transplantation is limited by islet graft failure because of poor
revascularization, host immune rejection, and nonspecific inflammatory response. Human …

Islet transplantation is limited by islet graft failure due to poor revascularization, host immune
rejection and nonspecific inflammatory response. Delivery of human vascular endothelial …

Purpose Ex vivo gene therapy approaches can improve the outcome of islet transplantation
for treating type I diabetes. We have previously shown the improvement in islet function and …

Ex vivo gene therapy approaches can improve the outcome of islet transplantation for
treating type I diabetes. We have recently shown improvement in islet survival and function …

Ex vivo gene transfer can improve the outcome of islet transplantation for treating type I
diabetes. Earlier we have shown coexpression of human vascular endothelial growth factor …

Successful islet transplantation depends on the infusion of sufficiently large quantities of
islets, of which only∼ 30% become stably engrafted. Rapid and adequate revascularization …

For gene transfer strategies to improve islet engraftment, vascular endothelial growth factor
(VEGF) expression should be regulated in a way that matches the transient nature of …

Background. Blood flow is impaired in islet transplants, but there is conflicting evidence on
improving the outcome by promoting vascularization. We previously reported that islet …

Transplantation of pancreatic islets has great potential for treating Type I diabetes. Ex vivo
gene therapy may promote re-vascularization or inhibit apoptosis of the islets and promote …

AIM: To determine whether the elevated vascular endothelial growth factor (VEGF)
expression produced by the transfected vascular endothelial cells (VECs) could stimulate …