Considerable advances in our understanding of the mechanisms by which drugs permeate
the skin barrier have been made over the past 60 years. The key publications, which have …

Over the past 30 or so years there has been a considerable advance in our knowledge of
the mechanisms of skin permeation. This has largely been brought about by the …

The assessment of percutaneous permeation of molecules is one of the main steps in the
initial design and later in the evaluation of dermal or transdermal drug delivery systems. The …

This article reviews some new mathematical models and techniques used to predict and
understand percutaneous penetration and transdermal delivery. These models are also …

Introduction Investigating the transportation of a drug molecule through various layers of skin
and determining the amount of drug retention in skin layers is of prime importance in …

The skin has evolved to prevent excessive water loss from the internal organs and to limit
the ability of xenobiotics and hazardous substances to enter the body. Notwithstanding this …

Attenuated-total-reflectance Fourier-transform-infrared spectroscopy has been used to
rapidly and noninvasively quantify in vivo the uptake of a chemical into the outermost, and …

Excised human skin is utilized for in vitro permeation experiments to evaluate the safety and
effect of topically-applied drugs by measuring its skin permeation and concentration …

Percutaneous Penetration Enhancers in a mini-series format comprising five volumes,
represents the most comprehensive reference on enhancement methods–both well …

The skin has been employed as a delivery route for localized as well as systemic delivery of
drugs. However, the Stratum corneum (SC) of the skin act as a main barrier for the …