Capsaicin sensitivity is associated with the expression of the vanilloid (capsaicin) receptor (VR1) mRNA in adult rat sensory ganglia

RJA Helliwell, LM McLatchie, M Clarke, J Winter… - Neuroscience …, 1998 - Elsevier
A vanilloid receptor (VR1) has recently been cloned and shown to be a target for capsaicin,
the excitotoxic component of capsicum peppers (Caterina, MJ, Schumacher, MA, Tominaga …

The tissue distribution and functional characterization of human VR1

DN Cortright, M Crandall, JF Sanchez, T Zou… - Biochemical and …, 2001 - Elsevier
The irritant action of capsaicin is mediated by the vanilloid receptor, VR1, which is
expressed in sensory neurons termed nociceptors. Capsaicin also desensitizes nociceptors …

Axonal transport of VR1 capsaicin receptor mRNA in primary afferents and its participation in inflammation‐induced increase in capsaicin sensitivity

C Tohda, M Sasaki, T Konemura… - Journal of …, 2001 - Wiley Online Library
Capsaicin receptors are expressed in primary sensory neurons and excited by heat and
protons. We examined the inflammation‐induced changes of the level of VR1 capsaicin …

Capsaicin receptor immunoreactivity in the human trigeminal ganglion

M Hou, R Uddman, J Tajti, M Kanje, L Edvinsson - Neuroscience letters, 2002 - Elsevier
The cloned capsaicin receptor, also known as vanilloid receptor subtype 1 (VR1) receptor,
has been demonstrated to be an integral membrane protein with homology to a family of …

Capsaicin activation of glutamatergic synaptic transmission in the rat locus coeruleus In vitro

S Marinelli, CW Vaughan, MDJ Christie… - The Journal of …, 2002 - Wiley Online Library
The vanilloid receptor protein (VR1) is a well‐characterised integrator of noxious stimuli in
peripheral sensory neurones. There is evidence for the presence of VR1 in the central …

The distribution and regulation of vanilloid receptor VR1 and VR1 5′ splice variant RNA expression in rat

JF Sanchez, JE Krause, DN Cortright - Neuroscience, 2001 - Elsevier
The vanilloid (capsaicin) receptor, VR1, is expressed in dorsal root ganglion and mediates
the sensory response to vanilloids and other noxious stimuli. There is evidence for VR1 …

Molecular cloning of an N-terminal splice variant of the capsaicin receptor: loss of N-terminal domain suggests functional divergence among capsaicin receptor …

MA Schumacher, I Moff, SP Sudanagunta… - Journal of Biological …, 2000 - ASBMB
Recently a cDNA clone, vanilloid receptor subtype-1 (VR1), was isolated and found to
encode an ion channel that is activated by both capsaicin, the pain producing compound in …

Expression of capsaicin receptor (VR1) by myelinated primary afferent neurons in rats

QP Ma - Neuroscience letters, 2002 - Elsevier
The expression of capsaicin (VR1) receptor by A-fiber primary afferent neurons has been
investigated by double immunohistochemical staining with VR1 and 200 kD neurofilament …

Capsaicin receptor in the pain pathway

M Tominaga, D Julius - The Japanese Journal of Pharmacology, 2000 - jstage.jst.go.jp
抄録 Capsaicin, the main pungent ingredient in 'hot'chili peppers, elicits burning pain by
activating specific (vanilloid) receptors on sensory nerve endings. The cloned capsaicin …

The responses of rat trigeminal ganglion neurons to capsaicin and two nonpungent vanilloid receptor agonists, olvanil and glyceryl nonamide

L Liu, YC Lo, IJ Chen, SA Simon - Journal of Neuroscience, 1997 - Soc Neuroscience
Capsaicin, the pungent ingredient in hot pepper, activates and subsequently desensitizes a
subset of polymodal nociceptors. Because its initial application to skin produces pain …