In the heart, secretory renin promotes hypertrophy, apoptosis, necrosis, fibrosis, and cardiac
failure through angiotensin generation from angiotensinogen. Thus, inhibitors of the renin …

One important goal in cardiology is to prevent necrotic cell death in the heart. Necrotic cell
death attracts neutrophils and monocytes into the injured myocardium. The consequences …

A stimulated renin-angiotensin system is known to promote oxidative stress, apoptosis,
necrosis and fibrosis. Renin transcripts (renin-b; renin-c) encoding a cytosolic renin isoform …

Background/Aims: Renin is known as a secretory glycoprotein that ultimately leads to
angiotensin II generation. In this way renin exerts pro-inflammatory effects and promotes …

Although the renin-angiotensin system usually promotes oxidative stress and cell death,
renin transcripts have been discovered, whose transcription product may be …

The renin‐angiotensin system promotes oxidative stress, apoptosis, necrosis, fibrosis, and
thus heart failure. Secretory renin plays a central role in these processes, initiating the …

The cardiac renin-angiotensin system has been suggested to be involved in various
pathological conditions, including hypertrophy and remodeling. However, direct evidence …

The renin-angiotensin system is known to regulate blood pressure as well as water-and
electrolyte balance. An activated RAS is involved in the development of hypertension and …

Renin is the rate‐limiting enzyme of the renin–angiotensin system cascade, which drives the
pathophysiological progression of heart failure. Species differences in the amino acid …

Heart failure (HF) patients frequently have elevated plasma renin activity. We examined the
significance of elevated plasma renin activity in a translationally-relevant model of dilated …