Cellular and molecular pathways of structural damage in rheumatoid arthritis

U Harre, G Schett - Seminars in immunopathology, 2017 - Springer
Structural damage of cartilage and bone tissue is a hallmark of rheumatoid arthritis (RA).
The resulting joint destruction constitutes one of the major disease consequences for …

[HTML][HTML] Pathogenetic mechanisms of posttraumatic osteoarthritis: opportunities for early intervention

WC Kramer, KJ Hendricks, J Wang - International journal of clinical …, 2011 - ncbi.nlm.nih.gov
Osteoarthritis (OA) is characterized by joint pain and stiffness with radiographic evidence of
joint space narrowing, osteophytes, and subchondral bone sclerosis. Posttraumatic OA …

[HTML][HTML] Osteoarthritis and cartilage regeneration: Focus on pathophysiology and molecular mechanisms

S Grässel, A Aszodi - International Journal of Molecular Sciences, 2019 - mdpi.com
Osteoarthritis (OA) is a leading cause of disability and source of societal cost in older adults.
It is a whole-joint disease in which all components of the joint are affected involving …

Recent progress in understanding molecular mechanisms of cartilage degeneration during osteoarthritis

M Wang, J Shen, H Jin, HJ Im… - Annals of the New …, 2011 - Wiley Online Library
Osteoarthritis (OA) is a highly prevalent disease affecting more than 20% of American adults.
Predispositions include joint injury, heredity, obesity, and aging. Biomechanical alterations …

Pathogenesis and treatment of osteoarthritis

VB Kraus - Medical Clinics, 1997 - medical.theclinics.com
The understanding of the pathogenesis of osteoarthritis (OA) has evolved considerably over
the past decade. Although the molecular causes of OA are still unknown, genetic …

[HTML][HTML] Healthy and osteoarthritis-affected joints facing the cellular crosstalk

S Semenistaja, S Skuja, A Kadisa, V Groma - International Journal of …, 2023 - mdpi.com
Osteoarthritis (OA) is a chronic, progressive, severely debilitating, and multifactorial joint
disease that is recognized as the most common type of arthritis. During the last decade, it …

[HTML][HTML] Osteochondral tissue repair in osteoarthritic joints: clinical challenges and opportunities in tissue engineering

M Tamaddon, L Wang, Z Liu, C Liu - Bio-design and manufacturing, 2018 - Springer
Osteoarthritis (OA), identified as one of the priorities for the Bone and Joint Decade, is one of
the most prevalent joint diseases, which causes pain and disability of joints in the adult …

[HTML][HTML] Osteoarthritis as an umbrella term for different subsets of humans undergoing joint degeneration: The need to address the differences to develop effective …

DA Hart - International Journal of Molecular Sciences, 2022 - mdpi.com
Osteoarthritis (OA) of joints such as the knee and hip are very prevalent, and the number of
individuals affected is expected to continue to rise. Currently, conservative treatments after …

[HTML][HTML] Osteoarthritis year in review 2023: Biology

AJ Roelofs, C De Bari - Osteoarthritis and cartilage, 2023 - Elsevier
Great progress continues to be made in our understanding of the multiple facets of
osteoarthritis (OA) biology. Here, we review the major advances in this field and progress …

[PDF][PDF] Osteoarthritis as an autoinflammatory disease caused by chondrocyte‐mediated inflammatory responses

YT Konttinen, T Sillat, G Barreto, M Ainola… - Arthritis & …, 2012 - academia.edu
Osteoarthritis (OA) is considered to be primarily a disease of the hyaline articular cartilage,
which secondarily affects subchondral bone and synovial membrane. The exact nature and …