Osteoarthritis (OA), the most common form of degenerative joint disease, is linked to high
morbidity. It is predicted to be the single greatest cause of disability in the general population …

Osteoarthritis (OA) is a disease that involves the entire joint, but its pathophysiology is not
well described. Alterations in peri-articular bone are an integral part of the OA disease …

Objective Despite many research efforts in recent decades, the major pathogenetic
mechanisms of osteoarthritis (OA), including gene alterations occurring during OA cartilage …

Inflammation, both locally in the joint and systemic, is nowadays considered among the
mechanisms involved in osteoarthritis (OA). However, this concept has not always been …

Mechanical joint loading is an essential factor in joint homeostasis but it is also the most
important aetiological factor in the development of osteoarthritis (OA). Although OA has long …

Osteoarthritis (OA) afflicts more than 20 million people in the United States and about 10% of
adults over the age of 50 years [1]. It has been demonstrated that 2.0% of women and 1.4 …

Purpose This manuscript will summarize the role of pro-inflammatory cytokines and tackle
newly discussed ones within the scope of OA pathogenesis as mentioned in the recent …

Osteoarthritis (OA) is a chronic, progressive degenerative whole joint disease that affects the
articular cartilage, subchondral bone, ligaments, capsule, and synovium. While it is still …

Osteoarthritis (OA) is a joint disorder involving cartilage degeneration and subchondral bone
sclerosis. The bone-cartilage interface is implicated in OA pathogenesis due to its …

Osteoarthritis (OA) has long been considered a “wear and tear” disease leading to loss of
cartilage. OA used to be considered the sole consequence of any process leading to …