Macro, micro, and molecular. Changes of the osteochondral interface in osteoarthritis development

X Fan, X Wu, R Crawford, Y Xiao… - Frontiers in Cell and …, 2021 - frontiersin.org
Osteoarthritis (OA) is a long-term condition that causes joint pain and reduced movement.
Notably, the same pathways governing cell growth, death, and differentiation during the …

Age-related degeneration of articular cartilage in the pathogenesis of osteoarthritis: molecular markers of senescent chondrocytes

G Musumeci, MA Szychlinska, A Mobasheri - 2015 - digitum.um.es
Aging is a natural process by which every single living organism approaches its twilight of
existence in a natural way. However, aging is also linked to the pathogenesis of a number of …

Osteoarthritis, genetic and molecular mechanisms

P Ghosh, M Smith - Biogerontology, 2002 - Springer
Osteoarthritis (OA) is the most common musculoskeletal disorder world-wide and has
enormous social and economic consequences. OA is a multifactorial disorder in which …

[引用][C] What is new on osteoarthritis Front?

P Richette, T Funk-Brentano - Eur. Musculoskeletal Rev, 2010

The role of chondrocyte hypertrophy and senescence in osteoarthritis initiation and progression

YA Rim, Y Nam, JH Ju - International journal of molecular sciences, 2020 - mdpi.com
Osteoarthritis (OA) is the most common joint disease that causes pain and disability in the
adult population. OA is primarily caused by trauma induced by an external force or by age …

Pathophysiological perspective of osteoarthritis

MHM Yunus, A Nordin, H Kamal - Medicina, 2020 - mdpi.com
Osteoarthritis (OA) is the most well-known degenerative disease among the geriatric and is
a main cause of significant disability in daily living. It has a multifactorial etiology and is …

Influence of osteoarthritis grade on molecular signature of human cartilage

S Zhou, TS Thornhill, F Meng, L Xie… - Journal of …, 2016 - Wiley Online Library
Articular chondrocytes maintain cartilage matrix turnover and have the capacity for anabolic
and catabolic activities that can be influenced by injury and disease. This study tested the …

[HTML][HTML] Articular cartilage and osteochondral tissue engineering techniques: Recent advances and challenges

W Wei, H Dai - Bioactive materials, 2021 - Elsevier
In spite of the considerable achievements in the field of regenerative medicine in the past
several decades, osteochondral defect regeneration remains a challenging issue among …

Intraarticular ligament degeneration is interrelated with cartilage and bone destruction in osteoarthritis

G Schulze-Tanzil - Cells, 2019 - mdpi.com
Osteoarthritis (OA) induces inflammation and degeneration of all joint components including
cartilage, joint capsule, bone and bone marrow, and ligaments. Particularly intraarticular …

[PDF][PDF] Clinical aspects, pathology and pathophysiology of osteoarthritis

SR Goldring, MB Goldring - Journal of musculoskeletal and neuronal …, 2006 - ismni.org
377 factors interact and that obesity, female sex and pre-existing early-stage OA contributed
significantly to an adverse radiographic and clinical OA outcome. Whereas it is clear that …