Lung cancer is a leading cause of death world-wide and the long-term survival rate for lung
cancer patients is one of the lowest for any cancer. New therapies are urgently needed. The …

Viral and synthetic single-stranded RNAs are the ligands for Toll-like receptors 7 and 8
(TLR7 and TLR8). We have reported a novel class of synthetic oligoribonucleotides, referred …

CpG-oligonucleotides (CpG-ODN), which induce signaling through Toll-like receptor 9
(TLR9), are widely used as adjuvants in therapy against cancer. However, tumor cells …

Unmethylated cytosine-phosphorothioate-guanine (CpG)-containing oligodeoxynucleotides
(ODNs) are synthetic DNA sequences that mimic bacterial DNA, and are known to serve as …

Abstract Background CpG-oligonucleotides (CpG-ODN), which induce signaling through
Toll-like receptor 9 (TLR9), are currently under investigation as adjuvants in therapy against …

7346 Background: Synthetic oligodeoxynucleotides containing CpG motifs (CpG ODN)
activate innate and adaptive vertebrate immunity by signaling through the TLR9 receptor …

Tumor immunotherapies have shown promising antitumor effects, especially immune
checkpoint inhibitors (ICIs). However, only 12.46% of the patients benefit from the ICIs, the …

CpG-oligonucleotides (CpG-ODN), which induce signaling through Toll-like receptor 9
(TLR9), are currently under investigation as adjuvants in therapy against infections and …

Tumor immunotherapy has evolved from the use of crude bacterial extracts to chemically
synthesized ligands for specific immune receptors, such as Toll-like receptors (TLRs). One of …

The immune system has acquired increasing importance as a key player in cancer
maintenance and growth. Thus, modulating anti-tumor immune mediators has become an …