Inflammation and coagulation

M Levi - … : From Molecular and Cellular Mechanisms to the Clinic, 2017 - Wiley Online Library
In the majority of patients with systemic inflammatory conditions, some degree of activation
of coagulation is present. Increasing evidence points to an extensive cross‐talk between …

Coagulation and sepsis

M Levi, T van der Poll - Thrombosis research, 2017 - Elsevier
Severe sepsis is almost invariably associated with systemic activation of coagulation. There
is ample evidence that demonstrates a wide-ranging cross-talk between hemostasis and …

The impact of the inflammatory response on coagulation

CT Esmon - Thrombosis research, 2004 - Elsevier
Inflammation contributions to the thrombotic response involve both cellular and humoral
modulation. Inflammation impacts the initiation, propagation and the inhibitory phases of …

Two-way interactions between inflammation and coagulation

M Levi, T van der Poll - Trends in cardiovascular medicine, 2005 - Elsevier
Activation of inflammatory and coagulation pathways is important in the pathogenesis of
vascular disease. There is ample evidence that extensive cross-talk between these two …

The role of natural anticoagulants in the pathogenesis and management of systemic activation of coagulation and inflammation in critically ill patients

M Levi, T van der Poll - Seminars in thrombosis and …, 2008 - thieme-connect.com
Critically ill patients often have systemic activation of both inflammatory systems and
coagulation. Increasing evidence points to an extensive cross-talk between these two …

The coagulant response in sepsis and inflammation

M Levi - Hämostaseologie, 2010 - thieme-connect.com
Critically ill patients often have systemic activation of both inflammation and coagulation.
Increasing evidence points to an extensive cross-talk between these two systems, whereby …

Hemostasis and inflammation: two of a kind?

P Verhamme, MF Hoylaerts - Thrombosis journal, 2009 - Springer
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Inflammation and the activated protein C anticoagulant pathway

CT Esmon - Seminars in thrombosis and hemostasis, 2006 - thieme-connect.com
After a coagulation stimulus, the blood clotting cascade amplifies largely unchecked until
very high levels of thrombin are generated. Natural anticoagulant mechanisms (for example …

Systemic versus localized coagulation activation contributing to organ failure in critically ill patients

M Levi, T van der Poll, M Schultz - Seminars in immunopathology, 2012 - Springer
In the pathogenesis of sepsis, inflammation and coagulation play a pivotal role. Increasing
evidence points to an extensive cross-talk between these two systems, whereby …

Inflammation, sepsis, and coagulation

CT Esmon, K Fukudome, T Mather, W Bode… - …, 1999 - haematologica.org
The molecular links between inflammation and coagulation are unquestioned. Inflammation
promotes coagulation by leading to intravascular tissue factor expression, eliciting the …