[HTML][HTML] New antimicrobial peptide-antibiotic combination strategy for Pseudomonas aeruginosa inactivation

W Han, Z Wei, TA Camesano - Biointerphases, 2022 - pubs.aip.org
Novel antimicrobials or new treatment strategies are urgently needed to treat Pseudomonas
aeruginosa (P. aeruginosa) related infections and especially to address the problem of …

Anti-Pseudomonas aeruginosa activity of natural antimicrobial peptides when used alone or in combination with antibiotics

X Chen, S Su, Y Yan, L Yin, L Liu - Frontiers in Microbiology, 2023 - frontiersin.org
The World Health Organization has recently published a list of 12 drug-resistant bacteria that
posed a significant threat to human health, and Pseudomonas aeruginosa (P. aeruginosa) …

Development of a novel hybrid antimicrobial peptide for targeted killing of Pseudomonas aeruginosa

H Kim, JH Jang, SC Kim, JH Cho - European Journal of Medicinal …, 2020 - Elsevier
The emergence of multidrug-resistant (MDR) Pseudomonas aeruginosa, coupled with
shrinking antibiotic pipelines, has increased the demand for new antimicrobials with novel …

Activity of AMP2041 against human and animal multidrug resistant Pseudomonas aeruginosa clinical isolates

CS Cabassi, A Sala, D Santospirito, GL Alborali… - Annals of Clinical …, 2017 - Springer
Background Antimicrobial resistance is a growing threat to public health. Pseudomonas
aeruginosa is a relevant pathogen causing human and animal infections, frequently …

Synergy between Human Peptide LL-37 and Polymyxin B against Planktonic and Biofilm Cells of Escherichia coli and Pseudomonas aeruginosa

KE Ridyard, M Elsawy, D Mattrasingh, D Klein… - Antibiotics, 2023 - mdpi.com
The rise in antimicrobial resistant bacteria is limiting the number of effective treatments for
bacterial infections. Escherichia coli and Pseudomonas aeruginosa are two of the …

The mechanism of killing by the proline-rich peptide Bac7 (1–35) against clinical strains of Pseudomonas aeruginosa differs from that against other Gram-negative …

G Runti, M Benincasa, G Giuffrida… - Antimicrobial Agents …, 2017 - Am Soc Microbiol
Pseudomonas aeruginosa infections represent a serious threat to worldwide health. Proline-
rich antimicrobial peptides (PR-AMPs), a particular group of peptide antibiotics, have …

Delineating the Mechanism of Action of a Protease Resistant and Salt Tolerant Synthetic Antimicrobial Peptide against Pseudomonas aeruginosa

G Pandit, T Sarkar, S Debnath, P Satpati… - ACS …, 2022 - ACS Publications
Rapidly growing antimicrobial resistance (AMR) against antibiotics has propelled the
development of synthetic antimicrobial peptides (AMPs) as potential antimicrobial agents …

High-Throughput Identification of Antibacterials Against Pseudomonas aeruginosa

S Li, P She, L Zhou, X Zeng, L Xu, Y Liu… - Frontiers in …, 2020 - frontiersin.org
Antibiotic resistance is a growing public health concern, though the constant development of
new antibiotics. The combination of high-throughput screening and drug repurposing is an …

Importance of Tryptophan in Transforming an Amphipathic Peptide into a Pseudomonas aeruginosa-Targeted Antimicrobial Peptide

X Zhu, Z Ma, J Wang, S Chou, A Shan - PLoS one, 2014 - journals.plos.org
Here, we found that simple substitution of amino acids in the middle position of the
hydrophobic face of an amphipathic peptide RI16 with tryptophan (T9W) considerably …

Mechanisms driving the antibacterial and antibiofilm properties of Hp1404 and its analogue peptides against multidrug-resistant Pseudomonas aeruginosa

MK Kim, HK Kang, SJ Ko, MJ Hong, JK Bang… - Scientific reports, 2018 - nature.com
Hp1404, identified from the venom of the scorpion Heterometrus petersii, displays
antimicrobial activity with cytotoxicity. Several synthetic peptides were designed based on …