Thyroid dysfunction is an important public health problem, which affects 10% of the general
population and increases the risk of cardiovascular morbidity and mortality. Many aspects of …

Thyroid hormone is essential for normal metabolism and development, and overt
abnormalities in thyroid function lead to common endocrine disorders affecting …

Normal thyroid function is essential for health, but its genetic architecture remains poorly
understood. Here, for the heritable thyroid traits thyrotropin (TSH) and free thyroxine (FT4) …

For a long time it has been known that both hypo-and hyperthyroidism are associated with
an increased risk of morbidity and mortality. In recent years, it has also become clear that …

Abstract Effects of thyroid hormones in individual tissues are determined by many factors
beyond their serum levels, including local deiodination and expression and activity of thyroid …

Context: A common polymorphism in the gene encoding the activating deiodinase (Thr92Ala-
D2) is known to be associated with quality of life in millions of patients with hypothyroidism …

Hypothyroidism is the most common thyroid disorder, affecting about 5% of the general
population. Here we present the current largest genome-wide association study of …

Thyroid diseases, including autoimmune thyroid diseases and thyroid cancer, are known to
have high heritability. Family and twin studies have indicated that genetics plays a major …

Graves' disease is a common autoimmune disorder characterized by thyroid stimulating
hormone receptor autoantibodies (TRAb) and hyperthyroidism. To investigate the genetic …

Recent advances in our understanding of genetic-epigenetic interactions have unraveled
new mechanisms underlying the etiology of complex autoimmune diseases. Autoimmune …