Restoration of wild-type p53 activity in p53-null HL-60 cells confers multidrug sensitivity.
HL-60 cells that stably express transfected wild-type (wt) p53 were used to determine
whether restoration of wt p53 increased the chemosensitivity of cells that normally lack p53 …
whether restoration of wt p53 increased the chemosensitivity of cells that normally lack p53 …
Acute overexpression of wt p53 facilitates anticancer drug‐induced death of cancer and normal cells
MV Blagosklonny, WS El‐Deiry - International journal of cancer, 1998 - Wiley Online Library
The relationship between chemosensitivity and p53 is currently considered from two
mutually exclusive points of view:(1) wt p53 increases chemosensitivity due to apoptosis and …
mutually exclusive points of view:(1) wt p53 increases chemosensitivity due to apoptosis and …
Effects of p53 mutants on wild-type p53-mediated transactivation are cell type dependent.
The spectrum of p53 mutations differs among human cancer types. We have hypothesized
that the p53 mutational spectrum observed in particular tumor types reflects the functional …
that the p53 mutational spectrum observed in particular tumor types reflects the functional …
Disruption of p53 function sensitizes breast cancer MCF-7 cells to cisplatin and pentoxifylline
S Fan, ML Smith, DJ Rivert, D Duba, Q Zhan, KW Kohn… - Cancer research, 1995 - AACR
The possibility that appropriately designed chemotherapy could act selectively against p53-
defective tumor cells was explored in MCF-7 human breast cancer cells. These cells were …
defective tumor cells was explored in MCF-7 human breast cancer cells. These cells were …
Failure of wild-type p53 gene therapy in human cancer cells expressing a mutant p53 protein
A Vinyals, MA Peinado, M Gonzalez-Garrigues… - Gene therapy, 1999 - nature.com
The introduction of exogenous wild-type p53 into human cancer cells bearing p53 mutation
does not necessarily result in inhibition of tumor growth. We have demonstrated this in MDA …
does not necessarily result in inhibition of tumor growth. We have demonstrated this in MDA …
Sensitivity of anticancer drugs in Saos-2 cells transfected with mutant p53 varied with mutation point.
LH Wang, K Okaichi, M Ihara, Y Okumura - Anticancer research, 1998 - europepmc.org
A human osteosarcoma cell line, Saos-2, which is devoid of endogenous p53 gene, and
clones of Saos-2 cells, which were transfected with wild type p53 or mutant p53 genes …
clones of Saos-2 cells, which were transfected with wild type p53 or mutant p53 genes …
The dual role of mutant p53 protein in chemosensitivity of human cancers.
H Mueller, U Eppenberger - Anticancer research, 1996 - europepmc.org
Mutational loss of p53 tumor suppressor functions has been observed in a wide range of
neoplasms and was associated with either enhanced or decreased chemosensitivity of …
neoplasms and was associated with either enhanced or decreased chemosensitivity of …
Early ultraviolet B-induced G1 arrest and suppression of the malignant phenotype by wild-type p53 in human squamous cell carcinoma cells
SJ Courtois, CD Woodworth, H Degreef… - Experimental cell …, 1997 - Elsevier
Wild-type p53 (wt-p53) negatively controls cell cycle progression after cellular stress
mediating either a temporary growth arrest or apoptosis, depending on the cell type and …
mediating either a temporary growth arrest or apoptosis, depending on the cell type and …
Endogenous p53 gene status predicts the response of human squamous cell carcinomas to wild-type p53
LS St John, ER Sauter, M Herlyn, S Litwin… - Cancer gene …, 2000 - nature.com
Prior reports suggest that p53 protein status may influence the response to gene
transduction with wild-type (wt) p53. Adenoviral vectors containing the p53 gene were …
transduction with wild-type (wt) p53. Adenoviral vectors containing the p53 gene were …
Prevention of fluorodeoxyuridine-induced cytotoxicity and DNA damage in HT29 colon carcinoma cells by conditional expression of wild-type p53 phenotype
LA Parsels, RC Zellars, TL Loney, JD Parsels… - Molecular …, 1997 - ASPET
We have examined the effects of conditionally expressing wild-type p53 activity in HT29
cells on DNA damage and cytotoxicity caused by exposure to fluorodeoxyuridine (FdUrd) …
cells on DNA damage and cytotoxicity caused by exposure to fluorodeoxyuridine (FdUrd) …