The future of drug development for inflammatory bowel disease: the need to ACT (advanced combination treatment)
The expanding therapeutic armamentarium available for inflammatory bowel disease (IBD)
as well as multiple compounds in clinical development inevitably raises questions as to their …
as well as multiple compounds in clinical development inevitably raises questions as to their …
The future of inflammatory bowel disease therapy: where do we go from here?
WJ Sandborn - Digestive Diseases, 2013 - karger.com
There are six important trends that will impact the future of inflammatory bowel disease
therapy.(1) Increased use of the biomarkers C-reactive protein (CRP) and fecal calprotectin …
therapy.(1) Increased use of the biomarkers C-reactive protein (CRP) and fecal calprotectin …
New targets in inflammatory bowel disease therapy: 2021
New targets in inflammatory bowel disease therapy: 2021 : Current Opinion in
Gastroenterology New targets in inflammatory bowel disease therapy: 2021 : Current …
Gastroenterology New targets in inflammatory bowel disease therapy: 2021 : Current …
[HTML][HTML] Advanced combination treatment with biologic agents and novel small molecule drugs for inflammatory bowel disease
The use of combination therapy with a biologic agent and immunosuppressant has well-
established efficacy and safety and is common practice in the management of inflammatory …
established efficacy and safety and is common practice in the management of inflammatory …
[HTML][HTML] Optimizing the use of current treatments and emerging therapeutic approaches to achieve therapeutic success in patients with inflammatory bowel disease
H Nakase - Gut and liver, 2020 - ncbi.nlm.nih.gov
The current goal of inflammatory bowel disease (IBD) treatment is a symptom-free everyday
life accompanied by mucosal healing with minimal use of corticosteroids. Recent therapeutic …
life accompanied by mucosal healing with minimal use of corticosteroids. Recent therapeutic …
New therapies for inflammatory bowel disease: from the bench to the bedside
S Danese - Gut, 2012 - gut.bmj.com
The mechanisms underlying the chronic intestinal inflammation that is a hallmark of
inflammatory bowel diseases (IBD) are complex. Components of the pathological response …
inflammatory bowel diseases (IBD) are complex. Components of the pathological response …
Rational combination therapy to overcome the plateau of drug efficacy in inflammatory bowel disease
C Stalgis, P Deepak, S Mehandru… - Gastroenterology, 2021 - gastrojournal.org
The first possibility is a precision medicine-like, biomarker-based approach as in oncology.
Availability of validated drug-specific or agnostic biomarkers targeting patients likely to …
Availability of validated drug-specific or agnostic biomarkers targeting patients likely to …
Landscape of new drugs and targets in inflammatory bowel disease
S Vieujean, F D'Amico, P Netter… - United European …, 2022 - Wiley Online Library
Although the therapeutic armamentarium of Inflammatory bowel diseases (IBD) physicians
has expanded rapidly in recent years, a proportion of patients remain with a suboptimal …
has expanded rapidly in recent years, a proportion of patients remain with a suboptimal …
Breaking through the therapeutic ceiling: what will it take?
T Raine, S Danese - Gastroenterology, 2022 - Elsevier
Outcomes for patients starting a new treatment for inflammatory bowel disease are
characterized by uncertainty of treatment response. Although it is natural to hope that new …
characterized by uncertainty of treatment response. Although it is natural to hope that new …
[HTML][HTML] Exploring the pipeline of novel therapies for inflammatory bowel disease; state of the art review
Crohn's disease (CD) and ulcerative colitis (UC), known as inflammatory bowel diseases
(IBD), are characterized by chronic inflammation of the gastrointestinal tract. Over the last …
(IBD), are characterized by chronic inflammation of the gastrointestinal tract. Over the last …
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