The future of drug development for inflammatory bowel disease: the need to ACT (advanced combination treatment)

S Danese, V Solitano, V Jairath, L Peyrin-Biroulet - Gut, 2022 - gut.bmj.com
The expanding therapeutic armamentarium available for inflammatory bowel disease (IBD)
as well as multiple compounds in clinical development inevitably raises questions as to their …

The future of inflammatory bowel disease therapy: where do we go from here?

WJ Sandborn - Digestive Diseases, 2013 - karger.com
There are six important trends that will impact the future of inflammatory bowel disease
therapy.(1) Increased use of the biomarkers C-reactive protein (CRP) and fecal calprotectin …

New targets in inflammatory bowel disease therapy: 2021

NA Cohen, DT Rubin - Current opinion in gastroenterology, 2021 - journals.lww.com
New targets in inflammatory bowel disease therapy: 2021 : Current Opinion in
Gastroenterology New targets in inflammatory bowel disease therapy: 2021 : Current …

[HTML][HTML] Advanced combination treatment with biologic agents and novel small molecule drugs for inflammatory bowel disease

V Solitano, C Ma, J Hanžel, R Panaccione… - Gastroenterology & …, 2023 - ncbi.nlm.nih.gov
The use of combination therapy with a biologic agent and immunosuppressant has well-
established efficacy and safety and is common practice in the management of inflammatory …

[HTML][HTML] Optimizing the use of current treatments and emerging therapeutic approaches to achieve therapeutic success in patients with inflammatory bowel disease

H Nakase - Gut and liver, 2020 - ncbi.nlm.nih.gov
The current goal of inflammatory bowel disease (IBD) treatment is a symptom-free everyday
life accompanied by mucosal healing with minimal use of corticosteroids. Recent therapeutic …

New therapies for inflammatory bowel disease: from the bench to the bedside

S Danese - Gut, 2012 - gut.bmj.com
The mechanisms underlying the chronic intestinal inflammation that is a hallmark of
inflammatory bowel diseases (IBD) are complex. Components of the pathological response …

Rational combination therapy to overcome the plateau of drug efficacy in inflammatory bowel disease

C Stalgis, P Deepak, S Mehandru… - Gastroenterology, 2021 - gastrojournal.org
The first possibility is a precision medicine-like, biomarker-based approach as in oncology.
Availability of validated drug-specific or agnostic biomarkers targeting patients likely to …

Landscape of new drugs and targets in inflammatory bowel disease

S Vieujean, F D'Amico, P Netter… - United European …, 2022 - Wiley Online Library
Although the therapeutic armamentarium of Inflammatory bowel diseases (IBD) physicians
has expanded rapidly in recent years, a proportion of patients remain with a suboptimal …

Breaking through the therapeutic ceiling: what will it take?

T Raine, S Danese - Gastroenterology, 2022 - Elsevier
Outcomes for patients starting a new treatment for inflammatory bowel disease are
characterized by uncertainty of treatment response. Although it is natural to hope that new …

[HTML][HTML] Exploring the pipeline of novel therapies for inflammatory bowel disease; state of the art review

Y Zurba, B Gros, M Shehab - Biomedicines, 2023 - mdpi.com
Crohn's disease (CD) and ulcerative colitis (UC), known as inflammatory bowel diseases
(IBD), are characterized by chronic inflammation of the gastrointestinal tract. Over the last …