Purpose.: To identify differential changes in proteins and metabolites underlying “fast” type 1
(T1DC) and “slow” type 2 (T2DC) diabetic cataract (DC) formation in rat. Methods.: Rat …

The glass‐like transparency of the human eye lens is achieved by the tight packing of
abundant crystallin proteins. However, the precise role of the accessory non‐crystallin …

Diabetes has become one of the major diseases affecting human health. Diabetic cataracts
(DCs) are considered a common complication in diabetic patients. The present study …

purpose. To identify modified crystallins associated with aging of lens and produce two-
dimensional electrophoresis (2-DE) proteome maps of crystallins in mouse lens. methods …

Aims/hypothesis Osmotic and oxidative stress is associated with the progression and
advancement of diabetic cataract. In the present study, we used a cDNA microarray method …

Crystallins are the major structural proteins in the vertebrate eye lens that contribute to lens
transparency. Although cataract, including diabetic cataract, is thought to be a result of the …

purpose. To investigate the influence of diabetes on the cleavage of C-terminal amino acid
residues of αA-and αB-crystallins in human and rat lenses. methods. The human lenses …

Purpose.: To investigate the tissue distribution and solubilities of various αA-crystallin
truncation products in the cataractous ICR/f rat model. Methods.: Rat lenses from …

Streptozotocin (STZ)‑induced diabetic rats (STZ rats) were used to investigate diabetic
cataracts. In the current study, a shotgun liquid chromatography (LC)/mass spectrometry …

To assess the significance of glycation, nonenzymatic browning, and oxidation of lens
crystallins in cataract formation in elderly diabetic patients, we measured three distinct …