Mitochondria play a central role in the regulation of energy metabolism in oocytes and
preimplantation embryos, where the number and morphology of mitochondria and …

Caseinolytic peptidase P mediates degradation of unfolded mitochondrial proteins and
activates mitochondrial unfolded protein response (mt UPR) to maintain protein …

Reduced quality in oocytes from women of advanced maternal age (AMA) is associated with
dysfunctional mitochondria. The objective of this study was to investigate the mechanisms …

Mitochondria perform essential roles as crucial organelles for cellular and systemic energy
homeostasis, and as signaling hubs, which coordinate nuclear transcriptional responses to …

During mitochondrial dysfunction or the accumulation of unfolded proteins within
mitochondria, cells employ a transcriptional response known as the mitochondrial unfolded …

Mitochondria are required for numerous essential metabolic processes including the
regulation of apoptosis; therefore, proper maintenance of the mitochondrial proteome is …

Mitochondria undergo continuous challenges in the course of their life, from their generation
to their degradation. These challenges include the management of reactive oxygen species …

During development and cellular differentiation, tissue-and cell-specific programs mediate
mitochondrial biogenesis to meet physiological needs. However, environmental and …

Mitochondria are multifaceted and indispensable organelles required for cell performance.
Accordingly, dysfunction to mitochondria can result in cellular decline and possibly the onset …

Maintenance of the mitochondrial proteome is performed primarily by chaperones, which
fold and assemble proteins, and by proteases, which degrade excess damaged proteins …