Cardiac remodelling is a key risk factor for the development of heart failure in the chronic
phase following myocardial infarction. Our previous studies have shown an anti-remodelling …

Angiotensin-converting enzyme (ACE) 2 is a recently identified homologue of ACE. There is
great interest in the therapeutic benefit for ACE2 overexpression in the heart. However, the …

Angiotensin converting enzyme 2 (ACE2) has been linked to cardiac dysfunction and
hypertension-induced cardiac pathophysiology. In this study, we used a gene …

Aims Angiotensin converting enzyme (ACE) 2 catalyses the cleavage of angiotensin (Ang) I
to Ang 1‐9 and of Ang II to Ang 1‐7. ACE2 deficiency impairs cardiac contractility and …

Fibroblasts play a pivotal role in cardiac remodeling and the development of heart failure
through the deposition of extra-cellular matrix (ECM) proteins and also by affecting …

Angiotensin-converting enzyme 2 (ACE2) is present in the heart and thought to exert
protective functions. We conducted studies in ACE2 deficient mice to determine whether …

The purpose of this study was to test the hypothesis that overexpression of angiotensin-
converting enzyme 2 (ACE2) may favorably affect left ventricular (LV) remodeling and …

Abstract Angiotensin-converting enzyme 2 (ACE2) metabolizes Ang II into Ang 1–7 thereby
negatively regulating the renin-angiotensin system. However, heart disease in humans and …

In order to investigate the role of angiotensin-converting enzyme 2 (ACE2) in cardiac
development, we examined the effects of ACE2 deficiency on postnatal development of the …

Objectives: The aim of this study was to test the hypothesis that angiotensin (Ang)-converting
enzyme-2 (ACE2) overexpression may inhibit myocardial collagen accumulation and …