ProBDNF induces neuronal apoptosis via activation of a receptor complex of p75NTR and sortilin
HK Teng, KK Teng, R Lee, S Wright… - Journal of …, 2005 - Soc Neuroscience
Brain-derived neurotrophic factor (BDNF) is best characterized for critical roles in neuronal
survival, differentiation, and synaptic modulation mediated by the TrkB receptor tyrosine …
survival, differentiation, and synaptic modulation mediated by the TrkB receptor tyrosine …
Proneurotrophin-3 is a neuronal apoptotic ligand: evidence for retrograde-directed cell killing
Although mature neurotrophins are well described trophic factors that elicit retrograde
survival signaling, the precursor forms of neurotrophins (ie, proneurotrophins) can function …
survival signaling, the precursor forms of neurotrophins (ie, proneurotrophins) can function …
ProNGF, but not NGF, switches from neurotrophic to apoptotic activity in response to reductions in TrkA receptor levels
MS Ioannou, M Fahnestock - International journal of molecular sciences, 2017 - mdpi.com
Nerve growth factor (NGF) promotes the survival and differentiation of neurons. NGF is
initially synthesized as a precursor, proNGF, which is the predominant form in the central …
initially synthesized as a precursor, proNGF, which is the predominant form in the central …
Differential effects of pro‐BDNF on sensory neurons after sciatic nerve transection in neonatal rats
Brain‐derived neurotrophic factor (BDNF) plays a critical role in the development of the
central and peripheral nervous systems, and also in neuronal survival after injury. The …
central and peripheral nervous systems, and also in neuronal survival after injury. The …
Roles for the pro-neurotrophin receptor sortilin in neuronal development, aging and brain injury
P Jansen, K Giehl, JR Nyengaard, K Teng… - Nature …, 2007 - nature.com
Neurotrophins are essential for development and maintenance of the vertebrate nervous
system. Paradoxically, although mature neurotrophins promote neuronal survival by binding …
system. Paradoxically, although mature neurotrophins promote neuronal survival by binding …
Understanding proneurotrophin actions: Recent advances and challenges
KK Teng, S Felice, T Kim… - Developmental …, 2010 - Wiley Online Library
Neurotrophins are initially synthesized as larger precursors (proneurotrophins), which
undergo proteolytic cleavage to yield mature forms. Although the functions of the mature …
undergo proteolytic cleavage to yield mature forms. Although the functions of the mature …
Endogenous brain-derived neurotrophic factor and neurotrophin-3 antagonistically regulate survival of axotomized corticospinal neurons in vivo
KM Giehl, S Röhrig, H Bonatz, M Gutjahr… - Journal of …, 2001 - Soc Neuroscience
Neuronal growth factors regulate the survival of neurons by their survival and death-
promoting activity on distinct populations of neurons. The neurotrophins nerve growth factor …
promoting activity on distinct populations of neurons. The neurotrophins nerve growth factor …
The secreted brain‐derived neurotrophic factor precursor pro‐BDNF binds to TrkB and p75NTR but not to TrkA or TrkC
B Fayard, S Loeffler, J Weis, E Vögelin… - Journal of …, 2005 - Wiley Online Library
The neurotrophin brain‐derived neurotrophic factor (BDNF) binds to two cell surface
receptors: TrkB receptors that promote neuronal survival and differentiation and p75NTR …
receptors: TrkB receptors that promote neuronal survival and differentiation and p75NTR …
NGF induces apoptosis in a human neuroblastoma cell line expressing the neurotrophin receptor p75NTR
P Kuner, C Hertel - Journal of neuroscience research, 1998 - Wiley Online Library
Nerve growth factor (NGF) has been demonstrated to support survival and differentiation of
neuronal cells. Recently, a role of NGF in neuronal apoptosis has been suggested. NGF …
neuronal cells. Recently, a role of NGF in neuronal apoptosis has been suggested. NGF …
Interaction of survival and death signaling in basal forebrain neurons: roles of neurotrophins and proneurotrophins
M Volosin, W Song, RD Almeida… - Journal of …, 2006 - Soc Neuroscience
Proneurotrophins bind with high affinity to p75 neurotrophin receptor (p75NTR) and lack the
capacity to bind Trk receptors, suggesting that proneurotrophins can elicit apoptosis via …
capacity to bind Trk receptors, suggesting that proneurotrophins can elicit apoptosis via …