Neurite outgrowth inhibition by chondroitin sulfate proteoglycan: stalling/stopping exceeds turning in human neuroblastoma growth cones

DAL Hynds, DM Snow - Experimental neurology, 1999 - Elsevier
Chondroitin sulfate proteoglycan (CSPG) inhibits outgrowth from embryonic chick and
rodent neurons in vivo and in vitro and is upregulated during development and following …

Inhibition of neurite growth by the NG2 chondroitin sulfate proteoglycan

CL Dou, JM Levine - Journal of Neuroscience, 1994 - Soc Neuroscience
The chondroitin sulfate proteoglycans (CSPGs) have been implicated as both positive and
negative modulators of axonal growth; however, the functional properties of only a few …

Effect of chondroitin sulfate proteoglycans on neuronal cell adhesion, spreading and neurite growth in culture

J Jin, S Tilve, Z Huang, L Zhou… - Neural Regeneration …, 2018 - journals.lww.com
As one major component of extracellular matrix (ECM) in the central nervous system,
chondroitin sulfate proteoglycans (CSPGs) have long been known as inhibitors enriched in …

Neurite elongation on chondroitin sulfate proteoglycans is characterized by axonal fasciculation

DM Snow, JD Smith, AT Cunningham, J McFarlin… - Experimental …, 2003 - Elsevier
In the developing or regenerating nervous system, migrating growth cones are exposed to
regulatory molecules that positively and/or negatively affect guidance. Chondroitin sulfate …

Nervous system–derived chondroitin sulfate proteoglycans regulate growth cone morphology and inhibit neurite outgrowth: A light, epifluorescence, and electron …

DM Snow, N Mullins, DL Hynds - Microscopy research and …, 2001 - Wiley Online Library
Proteoglycans influence aging and plasticity in the nervous system. Particularly prominent
are the chondroitin sulfate proteoglycans (CSPGs), which are generally inhibitory to neurite …

Growth cone behavior in the presence of soluble chondroitin sulfate proteoglycan (CSPG), compared to behavior on CSPG bound to laminin or fibronectin

DM Snow, EM Brown, PC Letourneau - International Journal of …, 1996 - Elsevier
Proteoglycans (PGs) are complex macromolecules of the extracellular matrix (ECM) that
have a wide variety of effects on developing and regenerating neurons in vivo and in vitro …

The roles of neuronal and glial precursors in overcoming chondroitin sulfate proteoglycan inhibition

AR Ketschek, C Haas, G Gallo, I Fischer - Experimental neurology, 2012 - Elsevier
The extension of axons through the major inhibitory component of the glial scar, chondroitin
sulfate proteoglycans (CSPGs), remains a key obstacle for regeneration following spinal …

Neurite outgrowth on a step gradient of chondroitin sulfate proteoglycan (CS‐PG)

DM Snow, PC Letourneau - Journal of neurobiology, 1992 - Wiley Online Library
Sulfated proteoglycans (PG s) may play a significant role in the regulation of neurite
outgrowth. They are present in axon-free regions of the developing nervous system and …

Inhibitory effects of brain chondroitin sulfate proteoglycans on neurite outgrowth from PC12D cells

A Oohira, F Matsui, R Katoh-Semba - Journal of Neuroscience, 1991 - Soc Neuroscience
Soluble chondroitin sulfate proteoglycans (CSPGs), prepared from 10-d-old rat brain, were
added to the culture medium of PC12D cells containing NGF to examine the effects on NGF …

Inhibition and enhancement of neural regeneration by chondroitin sulfate proteoglycans

H Rauvala, M Paveliev, J Kuja-Panula… - Neural regeneration …, 2017 - journals.lww.com
The current dogma in neural regeneration research implies that chondroitin sulfate
proteoglycans (CSPGs) inhibit plasticity and regeneration in the adult central nervous …