Optimal regulation of immune networks is essential for the generation of effective immune
responses, and defects in such networks can lead to immunodeficiency while uncontrolled …

mTOR is an evolutionarily conserved serine/threonine kinase that plays a critical role in cell
growth and metabolism by sensing different environmental cues. There is a growing …

mTOR is an evolutionarily conserved serine/threonine kinase that plays a central role in
integrating environmental cues in the form of growth factors, amino acids, and energy. In the …

The mammalian target of rapamycin (mTOR), a phosphoinositide-3-kinase-related protein
kinase, acts as a rheostat capable of integrating a variety of environmental cues in the form …

The evolutionarily conserved kinase mTOR (mammalian target of rapamycin) couples cell
growth and metabolism to environmental inputs in eukaryotes. T cells depend on mTOR …

The mechanistic target of rapamycin (mTOR) signaling integrates diverse environmental
cues, including growth factors, nutrients and immunological signals. Activation of mTOR …

Abstract mTOR signaling links bioenergetic and biosynthetic metabolism to immune
responses. mTOR is activated by diverse upstream stimuli, including immune signals …

The innate inflammatory immune response must be tightly controlled to avoid damage to the
host. Here, we showed that the tuberous sclerosis complex-mammalian target of rapamycin …

The kinase mTOR has emerged as an important regulator of the differentiation of helper T
cells. Here we demonstrate that differentiation into the TH1 and TH17 subsets of helper T …

Highlights•A fine-tuned mTOR activity is required for proper function of T cells.•Both
mTORC1 and mTORC2 contribute to Tfh cell differentiation.•Multiple upstream signaling …