Phosphodiesterases (PDEs) are enzymes that hydrolyze and inactivate 3′, 5′-cyclic
adenosine monophosphate (cAMP) and/or 3′, 5′-cyclic guanosine monophosphate …

The nucleotide second messenger 3′, 5′-cyclic adenosine monophosphate (cAMP) and
3′, 5′-cyclic guanosine monophosphate (cGMP) mediate fundamental functions of the …

Abstract Rationale Phosphodiesterases (PDEs) play an important role in the regulation of
intracellular signaling mediated by cyclic adenosine monophosphate (cAMP). Recently …

Abstract Changes in the cyclic adenosine monophosphate (cAMP) and cyclic guanosine
monophosphate (cGMP) signaling are implicated in older people with dementia. Drugs that …

As the population of older individuals grows worldwide, researchers have increasingly
focused their attention on identifying key molecular targets of age-related cognitive …

Background: Previous studies have shown that cyclic nucleotide phosphodiesterase type 5
(PDE5) inhibition with the drugs sildenafil and vardenafil can enhance spatial performance …

Understanding the cellular and molecular processes involved in learning and memory will
help in the development of safe and effective cognitive enhancers. The cAMP response …

An effective treatment for age-related cognitive deficits remains an unmet medical need.
Currently available drugs for the symptomatic treatment of Alzheimer's disease or other …

Aging is associated with declines in memory and cognitive function. Here, we evaluate the
effects of HT-0712 on memory formation and on cAMP response element-binding protein …

Cyclic nucleotides cAMP and cGMP cooperate to ensure memory acquisition and
consolidation. Increasing their levels by phosphodiesterase inhibitors (PDE-Is) enhanced …