Since the discovery in the 1970s that plasma levels of high-density lipoprotein cholesterol
(HDL-C) are inversely associated with cardiovascular outcome, it has been postulated that …

For a long time, high-density lipoprotein cholesterol (HDL-C) has been regarded as a
cardiovascular disease (CVD) protective factor. Recently, several epidemiological studies …

High-density lipoprotein (HDL) particles are highly complex polymolecular aggregates
capable of performing a remarkable range of atheroprotective functions. Considerable …

High-density lipoprotein cholesterol (HDL-C) has been identified as a powerful independent
negative predictor of cardiovascular disease. The beneficial effect of HDL is largely …

The risk of atherosclerosis is inversely related to circulating levels of high density lipoprotein
(HDL) cholesterol. Notably, in large-scale epidemiologic studies, this association is …

Clinical data show that a 1% increase in serum concentrations of high-density lipoprotein
cholesterol (HDL-C) can decrease cardiovascular risk by 2% to 3%. Therefore, mechanisms …

The last 20 years have witnessed dramatic reductions in cardiovascular risk using 3-hydroxy-
3-methylglutaryl coenzyme A reductase inhibitors (“statins”) to lower levels of low-density …

High-density lipoprotein (HDL) has received increasing interest due to observations of an
inverse relationship between its systemic levels and cardiovascular risk and targeted …

Formation of plaques in artery walls, or atherogenesis, is known to lead to cardiovascular
disease risk and heart disease. Low-density lipoproteins (LDLs), which deliver cholesterol to …

The vast majority of research about HDL (high-density lipoprotein) has for decades revolved
around the possible role of HDL in atherosclerosis and its therapeutic potential within …