Alcohol consumption and cognitive performance: a M endelian randomization study

M Kumari, MV Holmes, CE Dale, JA Hubacek… - …, 2014 - Wiley Online Library
Aims To use M endelian randomization to assess whether alcohol intake was causally
associated with cognitive function. Design M endelian randomization using a genetic variant …

Evaluation of moderate alcohol use and cognitive function among men using a Mendelian randomization design in the Guangzhou biobank cohort study

SL Au Yeung, CQ Jiang, KK Cheng… - American journal of …, 2012 - academic.oup.com
Observational studies usually show that moderate alcohol use is associated with better
cognitive function. Such studies are vulnerable to residual confounding arising from …

Alcohol consumption and lifetime change in cognitive ability: a gene× environment interaction study

SJ Ritchie, TC Bates, J Corley, G McNeill, G Davies… - Age, 2014 - Springer
Studies of the effect of alcohol consumption on cognitive ability are often confounded. One
approach to avoid confounding is the Mendelian randomization design. Here, we used such …

Polygenic risk for alcohol dependence associates with alcohol consumption, cognitive function and social deprivation in a population‐based cohort

TK Clarke, AH Smith, J Gelernter, HR Kranzler… - Addiction …, 2016 - Wiley Online Library
Alcohol dependence is frequently co‐morbid with cognitive impairment. The relationship
between these traits is complex as cognitive dysfunction may arise as a consequence of …

Alcohol use and cognitive functioning in young adults: improving causal inference

L Mahedy, S Suddell, C Skirrow, GS Fernandes… - …, 2021 - Wiley Online Library
Abstract Background and Aims There have been few longitudinal studies of association
between alcohol use and cognitive functioning in young people. We aimed to examine …

Association of the alcohol dehydrogenase gene polymorphism rs1789891 with gray matter brain volume, alcohol consumption, alcohol craving and relapse risk

P Bach, E Zois, S Vollstädt‐Klein, M Kirsch… - Addiction …, 2019 - Wiley Online Library
Alcohol metabolizing enzymes, such as the alcohol dehydrogenases and the aldehyde
dehydrogenases, regulate the levels of acetaldehyde in the blood and play an important role …

Educational attainment impacts drinking behaviors and risk for alcohol dependence: results from a two-sample Mendelian randomization study with~ 780,000 …

DB Rosoff, TK Clarke, MJ Adams, AM McIntosh… - Molecular …, 2021 - nature.com
Observational studies suggest that lower educational attainment (EA) may be associated
with risky alcohol use behaviors; however, these findings may be biased by confounding …

Alcohol consumption in men is influenced by qualitatively different genetic factors in adolescence and adulthood

AC Edwards, KS Kendler - Psychological medicine, 2013 - cambridge.org
BackgroundAlcohol consumption is influenced by genetic factors. Previous studies have
examined the heritability of alcohol consumption, or related phenotypes, from adolescence …

Potential influence of socioeconomic status on genetic correlations between alcohol consumption measures and mental health

AT Marees, DJA Smit, JS Ong, S MacGregor… - Psychological …, 2020 - cambridge.org
Background. Frequency and quantity of alcohol consumption are metrics commonly used to
measure alcohol consumption behaviors. Epidemiological studies indicate that these …

Alcohol consumption indices of genetic risk for alcohol dependence

JD Grant, A Agrawal, KK Bucholz, PAF Madden… - Biological …, 2009 - Elsevier
BACKGROUND: Previous research has reported a significant genetic correlation between
heaviness of alcohol consumption and alcohol dependence (AD), but this association might …