The activation of helper T cells by peptides bound to proteins of the class II Major
Histocompatibility Complex (MHC II) is pivotal to the initiation of an immune response. The …

To generate an effective immune response, class II major histocompatibility complex
molecules (MHCII) must present a diverse array of peptide ligands for recognition by T …

Hydrogen bonds (H-bonds) are crucial for the stability of the peptide-major histocompatibility
complex (MHC) complex. In particular, the H-bonds formed between the peptide ligand and …

The complexity of the interaction between major histocompatibility complex class II (MHC II)
proteins and peptide ligands has been revealed through structural studies and …

Background: Class II major histocompatibility complex (MHC) proteins are cell surface
glycoproteins that bind peptides and present them to T cells as part of the mechanism for …

The binding of peptides to MHC class II molecules is mediated in part by a conserved array
of intermolecular hydrogen bonds. We have evaluated the consequences of disrupting the …

Peptides bind to class II major histocompatibility complex (MHC) proteins in an extended
conformation. Pockets in the peptide binding site spaced to accommodate peptide side …

Major histocompatibility complex (MHC) molecules are a key element of the cellular immune
response. Encoded by the MHC they are a family of highly polymorphic peptide receptors …

Class I major histocompatibility complex (MHC) molecules interact with self and foreign
peptides of diverse amino acid sequences yet exhibit distinct allele-specific selectivity for …

The ability of MHC molecules to present a broad spectrum of peptide antigens for T cell
recognition requires a compromise between high affinity and broad specificity. Three …