Effect of aberrant p53 function on temozolomide sensitivity of glioma cell lines and brain tumor initiating cells from glioblastoma

MD Blough, DC Beauchamp, MR Westgate… - Journal of neuro …, 2011 - Springer
The most effective chemotherapeutic for glioblastoma (GBM) is the DNA alkylating agent
temozolomide (TMZ). In a recent study by Hegi et al. benefit from TMZ was significantly …
被引用次数：118 相关文章 所有 12 个版本
[PDF] academia.edu

Multifaceted resistance of gliomas to temozolomide

DB Bocangel, S Finkelstein, SC Schold, KK Bhakat… - Clinical cancer …, 2002 - AACR
Abstract Purpose and Experimental Design: The contributions of O 6-methylguanine-DNA-
methyltransferase (MGMT), p53 status, mismatch repair, and apoptotic response to the …
被引用次数：169 相关文章 所有 9 个版本
[PDF] academia.edu

O6‐methylguanine DNA methyltransferase and p53 status predict temozolomide sensitivity in human malignant glioma cells

M Hermisson, A Klumpp, W Wick… - Journal of …, 2006 - Wiley Online Library
Temozolomide (TMZ) is a methylating agent which prolongs survival when administered
during and after radiotherapy in the first‐line treatment of glioblastoma and which also has …
被引用次数：413 相关文章 所有 9 个版本
[HTML] oup.com

Prognostic Significance of O6-Methylguanine-DNA Methyltransferase Protein Expression in Patients with Recurrent Glioblastoma Treated with Temozolomide

M Nagane, K Kobayashi, A Ohnishi… - Japanese Journal of …, 2007 - academic.oup.com
Background: Temozolomide (TMZ) is active against newly diagnosed glioblastoma (GBM),
and O 6-methylguanine-DNA methyltransferase (MGMT) is implicated in resistance to TMZ …
被引用次数：77 相关文章 所有 12 个版本
[PDF] jst.go.jp

Efficacy of temozolomide is correlated with 1p loss and methylation of the deoxyribonucleic acid repair gene MGMT in malignant gliomas

D Ishii, A Natsume, T Wakabayashi… - Neurologia medico …, 2007 - jstage.jst.go.jp
Promoter methylation of the deoxyribonucleic acid (DNA) repair gene, O6-methylguanine-
DNA methyltransferase (MGMT), is associated with improved outcome of patients with …
被引用次数：40 相关文章 所有 8 个版本
[PDF] unito.it

MGMT promoter methylation in plasma of glioma patients receiving temozolomide

V Fiano, M Trevisan, E Trevisan, R Senetta… - Journal of neuro …, 2014 - Springer
Promoter methylation of the O6-methylguanine-DNA methyltransferase (MGMT) gene plays
a role in cellular response to alkylating agents. In the present study aimed to:(i) evaluate the …
被引用次数：57 相关文章 所有 12 个版本
[HTML] oup.com

Withholding temozolomide in glioblastoma patients with unmethylated MGMT promoter—still a dilemma?

ME Hegi, R Stupp - Neuro-oncology, 2015 - academic.oup.com
Ten years ago we established O-6-methylguanine-DNA methyltransferase (MGMT) gene
promoter methylation as the first predictive marker in neuro-oncology, and the strongest …
被引用次数：113 相关文章 所有 14 个版本
[HTML] mdpi.com

[HTML][HTML] On the critical issues in temozolomide research in glioblastoma: clinically relevant concentrations and MGMT-independent resistance

AA Stepanenko, VP Chekhonin - Biomedicines, 2019 - mdpi.com
The current standard first-line treatment for adult patients with newly diagnosed glioblastoma
includes concurrent radiotherapy and daily oral temozolomide (TMZ), followed by adjuvant …
被引用次数：23 相关文章 所有 9 个版本
[HTML] oup.com

New (alternative) temozolomide regimens for the treatment of glioma

W Wick, M Platten, M Weller - Neuro-oncology, 2009 - academic.oup.com
One barrier to successful treatment of malignant glioma is resistance to alkylating agents
such as temozolomide. The cytotoxic activity of temozolomide and other alkylating agents is …
被引用次数：214 相关文章 所有 8 个版本
[PDF] researchgate.net

Temozolomide-mediated radiation enhancement in glioblastoma: a report on underlying mechanisms

A Chakravarti, MG Erkkinen, U Nestler, R Stupp… - Clinical Cancer …, 2006 - AACR
Purpose: In this study, we investigated the mechanisms by which temozolomide enhances
radiation response in glioblastoma cells. Experimental Design: Using a panel of four primary …
被引用次数：267 相关文章 所有 14 个版本