Effects of heterozygous variants in the leptin-melanocortin pathway on Roux-en-Y gastric bypass outcomes: a 15-Year case–control study

A Campos, L Cifuentes, A Hashem, B Busebee… - Obesity surgery, 2022 - Springer
Introduction Heterozygous variants in the leptin-melanocortin pathway are associated with
obesity. However, their effect on the long-term outcomes after Roux-en-Y gastric bypass …

Effects of Heterozygous Variants in the Leptin-Melanocortin Pathway on Transoral Outlet Reduction After Roux-en-Y Gastric Bypass: A Case–Control Study and …

K Gala, W Ghusn, S Fansa, BK Abu Dayyeh… - Obesity Surgery, 2023 - Springer
Abstract Background Transoral outlet reduction (TORe) is a safe and effective technique for
management of weight regain (WR) after Roux-en-Y Gastric Bypass (RYGB). Carriers of a …

Predicting maximum Roux-en-Y gastric bypass-induced weight reduction—preoperative plasma leptin or body weight?

L Czupryniak, M Pawlowski, A Kumor, D Szymanski… - Obesity Surgery, 2007 - Springer
Background Weight loss after bariatric surgery varies between patients, and predicting the
extent thereof is often inaccurate. The aim of this study was to assess the potential of …

Leptin is required for glucose homeostasis after Roux-en-Y gastric bypass in mice

M Mokadem, JF Zechner, A Uchida, V Aguirre - PLoS One, 2015 - journals.plos.org
Background & Aims Leptin, the protein product of the ob gene, increases energy
expenditure and reduces food intake, thereby promoting weight reduction. Leptin also …

Genome-wide association of single-nucleotide polymorphisms with weight loss outcomes after Roux-en-Y gastric bypass surgery

ES Rinella, C Still, Y Shao, GC Wood… - The Journal of …, 2013 - academic.oup.com
Context: Roux-en-Y gastric bypass (RYGB) is among the most effective treatments for
extreme obesity and obesity-related complications. However, despite its potential efficacy …

Long-term changes in leptin, chemerin, and ghrelin levels following Roux-en-Y gastric bypass and laparoscopic sleeve gastrectomy

MA Salman, M El-Ghobary, A Soliman, M El Sherbiny… - Obesity surgery, 2020 - Springer
Aim Published reports showed conflicting results regarding the sustained alterations in
leptin, chemerin, and ghrelin concenratios after metabolic surgery. Therefore, we performed …

Changes in gastrointestinal hormones and leptin after Roux‐en‐Y gastric bypass surgery

LM Beckman, TR Beckman, SD Sibley… - Journal of Parenteral …, 2011 - Wiley Online Library
Background: Roux‐en‐Y gastric bypass (RYGB) imparts long‐term weight loss, the
mechanisms for which are not well understood. Changes in leptin and gastrointestinal (GI) …

Effects of two variants of Roux-en-Y gastric bypass on metabolism behaviour: focus on plasma ghrelin concentrations over a 2-year follow-up

N Pérez-Romero, A Serra, ML Granada, M Rull… - Obesity surgery, 2010 - Springer
Background To study the effects of two variants of Roux-en-Y gastric bypass (RYGBP) on
plasma ghrelin concentrations according to different exposure of gastric fundus to the …

Heritability of the weight loss response to gastric bypass surgery

IJ Hatoum, DM Greenawalt, C Cotsapas… - The Journal of …, 2011 - academic.oup.com
Abstract Context: The use of Roux-en-Y gastric bypass (RYGB) surgery to treat severe
obesity has grown dramatically. RYGB is highly effective, but the response in individual …

Non-responders after gastric bypass surgery for morbid obesity: peptide hormones and glucose homeostasis

E Sima, DL Webb, PM Hellström, M Sundbom - Obesity Surgery, 2019 - Springer
Introduction About 20% of patients operated with Roux-en-Y gastric bypass (RYGBP)
experience poor long-term weight result. This study compared levels of leptin and gut …