Toll-like receptors 7 and 8 (TLR7/8) are broadly expressed on antigen-presenting cells,
making TLR7/8 agonists likely candidates for the development of new vaccine adjuvants …

Toll‐like receptors (TLRs) are germline‐encoded receptors that are central to innate and
adaptive immune responses. Owing to their vital role in inflammation, TLRs are rational …

Toll-like receptor 9 has been the focus of considerable research attention for the ability to
modulate its activity, and subsequent innate immune responses, through DNA-based …

Human Toll-like receptor 8 (hTLR8) is expressed in myeloid dendritic cells, monocytes, and
monocyte-derived dendritic cells. Engagement by TLR8 agonists evokes a distinct cytokine …

Activation of human toll-like receptor-8 (TLR8) evokes a distinct cytokine profile favoring the
generation of Type 1 helper T cells. A multiplexed high-throughput screen had led to the …

Many inflammatory diseases may be linked to pathologically elevated signaling via the
receptor for lipopolysaccharide (LPS), toll-like receptor 4 (TLR4). There has thus been great …

Abstract Toll‐like receptor (TLR)‐8 agonists activate adaptive immune responses by
inducing robust production of T helper 1‐polarizing cytokines, suggesting that TLR8‐active …

There is a growing interest in the targeting of Toll-like receptors (TLRs) for the prevention
and treatment of cancer, rheumatoid arthritis, inflammatory bowel disease and systemic …

Innate immune cells have a critical role in defense against infection and disease. Central to
this is the broad specificity with which they can detect pathogen‐associated patterns and …

The family of Toll-like receptors (TLR1-TLR11) provides host defense in mammals by
inducing proinflammatory innate immune response upon recognition of conserved structural …